protein

Recombinant Human Progesterone Receptor

MBS143086

0.01 mg

610 USD

Recombinant Protein

Recombinant Human Progesterone Receptor

Progesterone Receptor

PGR Human; Progesterone Receptor Human Recombinant; Progesterone receptor; PR; Nuclear receptor subfamily 3 group C member 3; PGR; NR3C3

progesterone receptor isoform B; Progesterone receptor; progesterone receptor; nuclear receptor subfamily 3 group C member 3; progesterone receptor; Nuclear receptor subfamily 3 group C member 3

PGR

PGR; PGR; PR; NR3C3; NR3C3; PR

PRGR_HUMAN

E Coli

933

PGR in 50mM Tris-HCl, pH7.5, 10mM L-glutathione (reduced). Sterile Filtered clear solution.

Store vial at -20 degree C to -80 degree C. When stored at the recommended temperature, this protein is stable for 12 months.Please prevent freeze-thaw cycles.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins

Description: Progesterone Receptor Human Recombinant (a.a. 412-562) expressed in E Coli, shows a 43 kDa SDS-PAGE (including GST tag).The PGR is purified by proprietary chromatographic techniques. Introduction: PGR belongs to the steroid receptor superfamily. PGR is located on chromosome 11q22. The progesterone receptor is an intracellular steroid receptor that specifically binds progesterone. The progesterone receptor (PgR) is an estrogen-regulated protein. PGR mediates the physiological effects of progesterone, which plays a fundamental role in reproductive events associated with establishing and maintaining pregnancy. PGR uses 2 distinct promotors and translation start sites in the first exon to produce 2 isoforms, A & B, which differ in their molecular weight (isoform A has 165 additional amino acids at the N-terminus). The progesterone receptor has an amino and a carboxyl terminal, the regulatory domain between them, a DNA binding domain, the hinge section, and the hormone binding domain. If no hormone is bound the carboxyl terminal inhibits transcription. Binding to a hormone stimulates a structural change which eliminates the inhibitory action. Following the progesterone binding to the receptor, restructuring with dimerization begins and the complex enters the nucleus where it binds to DNA.It has been proposed that expression of PgR determination indicates a responsive estrogen receptor (ER) pathway, and therefore, may predict likely response to endocrine therapy in human breast cancer. A number of studies have shown that PgR determination provides supplementary information to ER, both in predicting response to endocrine therapy and estimating survival. PgR has proved superior to ER as a prognostic indicator in some studies.

110611914

NP_000917.3

NM_000926.4

P06401

87,747 Da

Cellular Roles Of Anthrax Toxin Pathway 138076!!Gene Expression Pathway 105937!!Generic Transcription Pathway 105938!!Nuclear Receptor Transcription Pathway 105979!!Nuclear Receptors Pathway 198848!!Nuclear Signaling By ERBB4 Pathway 530744!!Oocyte Meiosis Pathway 126909!!Oocyte Meiosis Pathway 126872!!Ovarian Infertility Genes Pathway 198801!!Progesterone-mediated Oocyte Maturation Pathway 119304

This gene encodes a member of the steroid receptor superfamily. The encoded protein mediates the physiological effects of progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This gene uses two distinct promotors and translation start sites in the first exon to produce two isoforms, A and B. The two isoforms are identical except for the additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Jan 2011]

0.01 mg

610 USD