protein

Recombinant Human Eukaryotic Translation Initiation Factor 4E-Binding Protein 1

MBS143083

0.01 mg

140 USD

Recombinant Protein

Recombinant Human Eukaryotic Translation Initiation Factor 4E-Binding Protein 1

Eukaryotic Translation Initiation Factor 4E-Binding Protein 1

EIF4EBP1 Human; Eukaryotic translation initiation factor 4E-binding protein 1 Human Recombinant; Eukaryotic translation initiation factor 4E-binding protein 1; eIF4E-binding protein 1; 4E-BP1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I; EIF4EBP1; BP-1; 4EBP1; MGC4316

eukaryotic translation initiation factor 4E-binding protein 1; Eukaryotic translation initiation factor 4E-binding protein 1; eukaryotic translation initiation factor 4E-binding protein 1; eIF4E-binding protein 1; phosphorylated heat- and acid-stable protein regulated by insulin 1; eukaryotic translation initiation factor 4E binding protein 1; Phosphorylated heat- and acid-stable protein regulated by insulin 1; PHAS-I

EIF4EBP1

EIF4EBP1; EIF4EBP1; BP-1; 4EBP1; 4E-BP1; PHAS-I; 4E-BP1; eIF4E-binding protein 1; PHAS-I

4EBP1_HUMAN

E Coli

118

Greater than 95.0% as determined by SDS-PAGE.

The EIF4EBP1 solution contains 20mM Tris-HCl buffer (pH8.0) and 10% glycerol. Sterile Filtered colorless solution.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Eukaryotic Translation Initiation Factor

Description: EIF4EBP1 Human Recombinant fused with a 20 amino acid His tag at N-terminus produced in E Coli is a single, non-glycosylated, polypeptide chain containing 138 amino acids (1-118 a.a.) and having a molecular mass of 14.7kDa (molecular weight on SDS-PAGE will appear higher).The EIF4EBP1 is purified by proprietary chromatographic techniques. Introduction: EIF4EBP1 (eukaryotic translation initiation factor 4E-binding protein 1) belongs to a family of translation repressor proteins. EIF4EBP1 regulates eIF4E (eukaryotic translation initiation factor 4E) activity by preventing its assembly into the eIF4F complex and mediates the regulation of protein translation by hormones, growth factors and other stimuli that signal through the MAP kinase and mTORC1 pathways. EIF4EBP1 is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. EIF4EBP1 C-terminus has domains which control function and phosphorylation. EIF4EBP1 has a role in progression of breast neoplasms through cell signaling.

4758258

NP_004086.1

NM_004095.3

Q13541

12,580 Da

AMPK Signaling Pathway 198868!!AMPK Signaling Pathway 989139!!AMPK Signaling Pathway 992181!!Activation Of The MRNA Upon Binding Of The Cap-binding Complex And EIFs, And Subsequent Binding To 43S Pathway 105970!!Acute Myeloid Leukemia Pathway 83117!!Acute Myeloid Leukemia Pathway 529!!Alpha6-Beta4 Integrin Signaling Pathway 198807!!BDNF Signaling Pathway 712093!!Cap-dependent Translation Initiation Pathway 105967!!Choline Metabolism In Cancer Pathway 1059539

This gene encodes one member of a family of translation repressor proteins. The protein directly interacts with eukaryotic translation initiation factor 4E (eIF4E), which is a limiting component of the multisubunit complex that recruits 40S ribosomal subunits to the 5' end of mRNAs. Interaction of this protein with eIF4E inhibits complex assembly and represses translation. This protein is phosphorylated in response to various signals including UV irradiation and insulin signaling, resulting in its dissociation from eIF4E and activation of mRNA translation. [provided by RefSeq, Jul 2008]

0.01 mg

140 USD