protein

Recombinant Human Profilin-1

MBS143080

0.01 mg

140 USD

Recombinant Protein

Recombinant Human Profilin-1

Profilin-1

PFN1 Human; Profilin-1 Human Recombinant; Profilin-1; Profilin I; PFN1

profilin-1; Profilin-1; profilin-1; epididymis tissue protein Li 184a; profilin I; profilin 1; Epididymis tissue protein Li 184a; Profilin I

PFN1

PFN1; PFN1; ALS18

PROF1_HUMAN

E Coli

140

MAGWNAYIDN LMADGTCQDA AIVGYKDSPS VWAAVPGKTF VNITPAEVGV LVGKDRSSFY VNGLTLGGQK CSVIRDSLLQ DGEFSMDLRT KSTGGAPTFN VTVTKTDKTL VLLMGKEGVH GGLINKKCYE MASHLRRSQY.

Greater than 95.0% as determined by SDS-PAGE.

The PFN1 protein solution contains 20mM Tris-HCl buffer (pH8.0) and 10% glycerol. Sterile Filtered colorless solution.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Profilin

Description: PFN1 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain containing 140 amino acids (1-140 a.a.) and having a molecular mass of 15kDa.The PFN1 is purified by proprietary chromatographic techniques. Introduction: Profilin1 (PFN1) is a ubiquitous actin monomer-binding protein which is a member of the profilin family. PFN1 significantly boosts skin wound healing in-vitro and in-vivo which may be mediated by purinergic receptors. PFN1 is also active in endothelial cell migration and vessel sprouting. PFN1 is thought to control actin polymerization in response to extracellular signals. PFN1 binds to actin and affects the formation of the cytoskeleton. In addition, PFN1 has an important role in the regulation of epithelial cell-cell adhesion. At high concentrations, profilin averts the polymerization of actin, while at low concentrations it enhances the polymerization. PFN1 gene deletion is linked to Miller-Dieker syndrome.

4826898

NP_005013.1

NM_005022.3

P07737

15,054 Da

Axon Guidance Pathway 105688!!Developmental Biology Pathway 477129!!G13 Signaling Pathway 198800!!Hemostasis Pathway 106028!!PCP/CE Pathway 1127528!!Platelet Activation, Signaling And Aggregation Pathway 106034!!Platelet Degranulation Pathway 106050!!Rap1 Signaling Pathway 868086!!Rap1 Signaling Pathway 878042!!Regulation Of Actin Cytoskeleton Pathway 198874

This gene encodes a member of the profilin family of small actin-binding proteins. The encoded protein plays an important role in actin dynamics by regulating actin polymerization in response to extracellular signals. Deletion of this gene is associated with Miller-Dieker syndrome, and the encoded protein may also play a role in Huntington disease. Multiple pseudogenes of this gene are located on chromosome 1. [provided by RefSeq, Jul 2012]

0.01 mg

140 USD