catalog number :
MBS143075
products type :
Native Protein
products full name :
Bovine Neurofilament Medium Polypeptide
products short name :
Neurofilament Medium
products name syn :
NEFM; Neurofilament Medium Polypeptide Bovine; Neurofilament medium polypeptide; NF-M; Neurofilament triplet M protein; 160 kDa neurofilament protein; Neurofilament 3; NEFM; NEF3; NFM
other names :
Neurofilament medium polypeptide; Neurofilament medium polypeptide; neurofilament medium polypeptide; 160 kDa neurofilament protein; major neuronal intermediate filament subunit; neurofilament 3; neurofilament M subunit; neurofilament triplet M protein; neurofilament, medium polypeptide; 160 kDa neurofilament protein; Neurofilament 3; Neurofilament triplet M protein
products gene name :
bNEFM
other gene names :
NEFM; NEFM; NEF3; NF-M; NEF3; NFM; NF-M
uniprot entry name :
NFM_BOVIN
host :
Bovine Spinal Cord
purity :
Greater than 98.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
form :
The protein was lyophilized from a 1mg/ml solution containing 10mM sodium phosphate, pH-7.5, 2mM DTT, 6M urea and 1mM EDTA. Sterile Filtered White lyophilized (freeze-dried) powder.
storage stability :
Lyophilized NEFM although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution NEFM should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.Please prevent freeze-thaw cycles.
other info2 :
Solubility: It is recommended to reconstitute the lyophilized NEFM in sterile 18M Omega -cm H2O.
products categories :
RECOMBINANT & NATURAL PROTEINS; Natural Proteins
products description :
Description: Ultra Pure NeuroFilament Protein having a Molecular mass of 160 kDa produced from Bovine Spinal Cord. Introduction: Neurofilaments are type IV intermediate filament heteropolymers that are composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber and may also have a role in intracellular transport to axons and dendrites. NeuroFilament 160kDa is a medium neurofilament protein, which is commonly used as a biomarker of neuronal damage.
ncbi mol weight :
103,210 Da
ncbi pathways :
Amyotrophic Lateral Sclerosis (ALS) Pathway (84338); Amyotrophic Lateral Sclerosis (ALS) Pathway (511)
uniprot summary :
NFM: a neurofilament intermediate filament protein. Neurofilaments usually contain three intermediate filament proteins: L, M, and H which are involved in the maintenance of neuronal caliber. The levels of phosphorylation are altered developmentally and coincident with a change in the neurofilament function. Protein type: Cytoskeletal. Cellular Component: neurofilament. Molecular Function: structural molecule activity