This webpage contains legacy information. The product is either no longer available from the supplier or has been delisted at Labome.
product summary
company name :
MyBioSource
product type :
protein
product name :
Recombinant Human Involucrin
catalog :
MBS143065
quantity :
0.002 mg
price :
265 USD
product information
catalog number :
MBS143065
products type :
Recombinant Protein
products full name :
Recombinant Human Involucrin
products short name :
Involucrin
products name syn :
Involucrin Human; Involucrin Human Recombinant; Involucrin; IVL; Involucrin
other names :
involucrin; Involucrin; involucrin; involucrin
other gene names :
IVL; IVL
uniprot entry name :
INVO_HUMAN
host :
E Coli
sequence length :
585
form :
Involucrin at 100 ug/ml in 50mM Tris-HCl, pH7.5, 10mM L-glutathione (reduced). Sterile Filtered clear solution.
storage stability :
Store vial at -20 degree C to -80 degree C. When stored at the recommended temperature, this protein is stable for 12 months.Please prevent freeze-thaw cycles.
tested application :
ELISA (EIA), Inhibition Assays, Western Blot (WB)
products categories :
RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins
products description :
Description: Involucrin Human Recombinant (aa 420-578) expressed in E Coli, shows a 41 kDa band on SDS-PAGE (Including GST tag).The Involucrin is purified by proprietary chromatographic techniques. Introduction: Involucrin is a soluble cytoplasmic protein precursor of the epidermal cornfied envelope that becomes cross-linked by transglutaminase during envelope assembly. Involucrin is expressed in a range of stratified squamous epithelia, including the cornea which lacks a distinct cornfied layer. The protein is a useful marker of terminal differentiation. It is tightly linked to the onset of differentiation and first expressed in the immediate suprabasal layers of the epidermis. Involucrin is mapped to 1q21 chromosome, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin.Involucrin's structure is composed of a conserved region of about 75 amino acid residues followed by two very variable length segments that contain glutamine-rich tandem repeats. The glutamine residues in the tandem repeats are the substrate for the tranglutaminase in the cross-linking reaction. The size of the protein varies from 285 residues (in dog) to 835 residues (in orangutan).
ncbi gi num :
44890059
ncbi acc num :
NP_005538.2
ncbi gb acc num :
NM_005547.2
uniprot acc num :
P07476
ncbi mol weight :
68,479 Da
ncbi pathways :
Corticotropin-releasing Hormone Pathway (920957); Validated Transcriptional Targets Of AP1 Family Members Fra1 And Fra2 Pathway (169349)
ncbi summary :
Involucrin, a component of the keratinocyte crosslinked envelope, is found in the cytoplasm and crosslinked to membrane proteins by transglutaminase. This gene is mapped to 1q21, among calpactin I light chain, trichohyalin, profillaggrin, loricrin, and calcyclin. [provided by RefSeq, Jul 2008]
uniprot summary :
IVL: Part of the insoluble cornified cell envelope (CE) of stratified squamous epithelia. Belongs to the involucrin family. Chromosomal Location of Human Ortholog: 1q21. Cellular Component: cytoplasm; cornified envelope. Molecular Function: protein binding, bridging; structural molecule activity. Biological Process: keratinocyte differentiation; isopeptide cross-linking via N6-(L-isoglutamyl)-L-lysine; keratinization; peptide cross-linking; response to UV-B
size1 :
0.002 mg
price1 :
265 USD
size2 :
0.005 mg
price2 :
365
size3 :
0.01 mg
price3 :
610
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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