catalog number :
MBS143059
products type :
Recombinant Protein
products full name :
Recombinant Human Fyn-p59
products short name :
Fyn-p59
products name syn :
p59-Fyn Human; p59-Fyn Human Recombinant; Proto-oncogene tyrosine-protein kinase Fyn; EC 2.7.10.2; p59-Fyn; Protooncogene Syn; SLK; FYN; MGC45350; Fyn p59
other names :
tyrosine-protein kinase Fyn isoform a; Tyrosine-protein kinase Fyn; tyrosine-protein kinase Fyn; FYN oncogene related to SRC, FGR, YES; OKT3-induced calcium influx regulator; c-syn protooncogene; proto-oncogene Syn; proto-oncogene c-Fyn; src-like kinase; src/yes-related novel; tyrosine kinase p59fyn(T); FYN proto-oncogene, Src family tyrosine kinase; Proto-oncogene Syn; Proto-oncogene c-Fyn; Src-like kinase; SLK; p59-Fyn
products gene name :
Fyn-p59
other gene names :
FYN; FYN; SLK; SYN; p59-FYN; SLK
uniprot entry name :
FYN_HUMAN
form :
p59-Fyn in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol. Sterile Filtered clear solution.
storage stability :
Store vial at -20 degree C to -80 degree C. When stored at the recommended temperature, this protein is stable for 12 months.Please prevent freeze-thaw cycles.
tested application :
ELISA (EIA), Inhibition Assays, Western Blot (WB)
products categories :
RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins
products description :
Description: p59-Fyn Human Recombinant (a.a. 23-216) expressed in E Coli, shows a 50 kDa SDS-PAGE (Including GST tag).The p59-Fyn is purified by proprietary chromatographic techniques. Introduction: p59-Fyn is a member of the protein-tyrosine kinase oncogene family. p59fyn is a membrane-associated non-receptor protein tyrosine kinase that belongs to the Src-family of kinases. p59-Fyn encodes a membrane-associated tyrosine kinase which is implicated in the control of cell growth. p59-Fyn associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. The unique N-terminal domain of p59fyn interacts with the CD3 and eta chains of the TcR. p59fyn can bind other proteins (p82 and p116) through its SH2 and SH3 domains, which may act as substrates or regulators of fyn activity. p59fyn is highly expressed in brain suggesting that it may have a role in the sensory nervous network and in myelination at early stages of CNS formation. Distinct isoforms exist due to alternative splicing.
ncbi acc num :
NP_002028.1
ncbi gb acc num :
NM_002037.5
ncbi mol weight :
54,513 Da
ncbi pathways :
Adaptive Immune System Pathway 366160!!Adherens Junction Pathway 83070!!Adherens Junction Pathway 481!!Alpha-synuclein Signaling Pathway 137913!!Alpha6-Beta4 Integrin Signaling Pathway 198807!!Angiopoietin Receptor Tie2-mediated Signaling Pathway 137917!!Antigen Activates B Cell Receptor (BCR) Leading To Generation Of Second Messengers Pathway 576249!!Axon Guidance Pathway 83065!!Axon Guidance Pathway 476!!Axon Guidance Pathway 105688
ncbi summary :
This gene is a member of the protein-tyrosine kinase oncogene family. It encodes a membrane-associated tyrosine kinase that has been implicated in the control of cell growth. The protein associates with the p85 subunit of phosphatidylinositol 3-kinase and interacts with the fyn-binding protein. Alternatively spliced transcript variants encoding distinct isoforms exist. [provided by RefSeq, Jul 2008]