protein

Recombinant Human Estrogen Receptor Alpha

MBS143052

0.002 mg

265 USD

Recombinant Protein

Recombinant Human Estrogen Receptor Alpha

Estrogen Receptor Alpha

ERa Human; Estrogen Receptor alpha Human Recombinant; Estrogen receptor; ER; Estradiol receptor; ER-alpha; Nuclear receptor subfamily 3 group A member 1; ESR1; ESR; NR3A1; Era; ESRA; DKFZp686N23123; ER-a; Estrogen Receptor alpha

estrogen receptor isoform 1; Estrogen receptor; estrogen receptor; ER-alpha; estradiol receptor; estrogen nuclear receptor alpha; estrogen receptor alpha E1-E2-1-2; estrogen receptor alpha E1-N2-E2-1-2; nuclear receptor subfamily 3 group A member 1; estrogen receptor 1; ER-alpha; Estradiol receptor; Nuclear receptor subfamily 3 group A member 1

ER-a

ESR1; ESR1; ER; ESR; Era; ESRA; ESTRR; NR3A1; ESR; NR3A1; ER

ESR1_HUMAN

E Coli

595

ER-alpha at 100 ug/ml in 50mM Tris-HCl, pH7.5 and 10mM L-glutathione (reduced). Sterile Filtered clear solution.

Store vial at -20 degree C to -80 degree C. When stored at the recommended temperature, this protein is stable for 12 months.Please prevent freeze-thaw cycles.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins

Description: ER-alpha Human Recombinant (a.a. 1-300) expressed in E Coli, shows a 59 kDa SDS-PAGE.The ER-alpha is purified by proprietary chromatographic techniques. Introduction: Estrogen receptor is a ligand-activated transcription factor composed of several domains essential for hormone binding, DNA binding, and activation of transcription. Estrogen and its receptors are crucial for sexual development and reproductive function, but also play a role in other tissues such as bone. The Estrogen Receptor is a significant regulator of growth and differentiation in the mammary gland. Estrogen receptors are also implicated in pathological processes including breast cancer, endometrial cancer, and osteoporosis. The presence of estrogen receptors in breast tumors indicates an increased probability of response to anti-estrogen therapy (e.g. tamoxifen).The Estrogen Receptor gene is divided into 8 exons having a genomic length of more than 140kbp.The Estrogen Receptor has 6 functionally separate domains, named A - F. Alternative splicing results in a number of transcript variations, which differ in their 5' UTRs and use different promoters. The protein is restricted to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2.

62821794

NP_000116.2

NM_000125.3

P03372

35,547 Da

Endocrine And Other Factor-regulated Calcium Reabsorption Pathway (213307); Endocrine And Other Factor-regulated Calcium Reabsorption Pathway (213276); Estrogen Signaling Pathway (799177); Estrogen Signaling Pathway (198863); Estrogen Signaling Pathway (799197); FOXA1 Transcription Factor Network Pathway (137979); FOXM1 Transcription Factor Network Pathway (137935); Gene Expression Pathway (105937); Generic Transcription Pathway (105938); Integrated Breast Cancer Pathway (219801)

This gene encodes an estrogen receptor, a ligand-activated transcription factor composed of several domains important for hormone binding, DNA binding, and activation of transcription. The protein localizes to the nucleus where it may form a homodimer or a heterodimer with estrogen receptor 2. Estrogen and its receptors are essential for sexual development and reproductive function, but also play a role in other tissues such as bone. Estrogen receptors are also involved in pathological processes including breast cancer, endometrial cancer, and osteoporosis. Alternative promoter usage and alternative splicing result in dozens of transcript variants, but the full-length nature of many of these variants has not been determined. [provided by RefSeq, Mar 2014]

ER-alpha: a nuclear hormone receptor and transcription factor. Regulates gene expression and affects cellular proliferation and differentiation in target tissues. Two splice-variant isoforms have been described. Protein type: DNA-binding; Nuclear receptor. Chromosomal Location of Human Ortholog: 6q25.1. Cellular Component: nucleoplasm; Golgi apparatus; membrane; cytoplasm; integral to membrane; plasma membrane; nucleus. Molecular Function: identical protein binding; estrogen receptor activity; zinc ion binding; nitric-oxide synthase regulator activity; beta-catenin binding; estrogen response element binding; transcription factor binding; steroid binding; protein binding; enzyme binding; steroid hormone receptor activity; chromatin binding; transcription factor activity. Biological Process: estrogen receptor signaling pathway; positive regulation of nitric oxide biosynthetic process; signal transduction; uterus development; response to estradiol stimulus; regulation of apoptosis; elevation of cytosolic calcium ion concentration; positive regulation of fibroblast proliferation; regulation of transcription, DNA-dependent; epithelial cell development; steroid hormone receptor signaling pathway; transcription initiation from RNA polymerase II promoter; transcription, DNA-dependent; positive regulation of nitric-oxide synthase activity; negative regulation of transcription factor activity; antral ovarian follicle growth; androgen metabolic process; male gonad development; vagina development; positive regulation of retinoic acid receptor signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB cascade; chromatin remodeling; response to estrogen stimulus; steroid hormone mediated signaling; G-protein signaling, coupled to IP3 second messenger (phospholipase C activating); positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; gene expression. Disease: Migraine With Or Without Aura, Susceptibility To, 1; Breast Cancer; Myocardial Infarction, Susceptibility To; Estrogen Resistance

0.002 mg

265 USD

0.005 mg

365

0.01 mg

610