protein

Recombinant Human Excision Repair Cross-Complementing 1, GST Tag

MBS143049

0.01 mg

610 USD

Recombinant Protein

Recombinant Human Excision Repair Cross-Complementing 1, GST Tag

Excision Repair Cross-Complementing 1

ERCC1 Human, GST; Excision Repair Cross-Complementing 1 Human Recombinant, GST Tag; Excision Repair Cross-complementing rodent repair deficiency complementation group 1 (includes overlapping antisense sequence); RAD10; COFS4; UV20; DNA excision repair protein ERCC-1; ERCC1, GST

DNA excision repair protein ERCC-1 isoform 3; DNA excision repair protein ERCC-1; DNA excision repair protein ERCC-1; excision repair cross-complementing rodent repair deficiency, complementation group 1 (includes overlapping antisense sequence); excision repair cross-complementation group 1

ERCC1

ERCC1; ERCC1; UV20; COFS4; RAD10

ERCC1_HUMAN

E Coli

273

ERCC1is supplied in 100 ug/ml in 50mM Tris-HCl (pH7.5) with 10mM L-glutathione (reduced). Sterile Filtered clear solution.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Excision Repair Cross-Complementing

Description: ERCC1 Human Recombinant produced in E Coli encoding human full length ERCC1 is fused to a GST tag and has a total molecular mass of 61kDa (including GST). The ERCC1 is purified by proprietary chromatographic techniques. Introduction: ERCC1 polypeptide is essential for nucleotide excision repair (NER) of damaged DNA and is homologous to Saccharomyces cerevisiae RAD10, which takes part in repair and mitotic intra-chromosomal recombination. NER mechanism includes dual incisions on both sides of the damage catalyzed by two nucleases. In mammalian cells XPG cleaves 3' of the DNA lesion while the ERCC1-XPF complex makes the 5' incision. Raised levels of ERCC1 were also found in cisplatin-resistant cells.

260593725

NP_001159521.1

NM_001166049.1

P07992

25,211 Da

DNA Repair Pathway 105837!!Dual Incision Reaction In GG-NER Pathway 105887!!Dual Incision Reaction In TC-NER Pathway 105892!!Fanconi Anemia Pathway 377262!!Fanconi Anemia Pathway 377128!!Formation Of Incision Complex In GG-NER Pathway 105886!!Formation Of Transcription-coupled NER (TC-NER) Repair Complex Pathway 105891!!Global Genomic NER (GG-NER) Pathway 105884!!Nucleotide Excision Repair Pathway 105883!!Nucleotide Excision Repair Pathway 83044

The product of this gene functions in the nucleotide excision repair pathway, and is required for the repair of DNA lesions such as those induced by UV light or formed by electrophilic compounds including cisplatin. The encoded protein forms a heterodimer with the XPF endonuclease (also known as ERCC4), and the heterodimeric endonuclease catalyzes the 5' incision in the process of excising the DNA lesion. The heterodimeric endonuclease is also involved in recombinational DNA repair and in the repair of inter-strand crosslinks. Mutations in this gene result in cerebrooculofacioskeletal syndrome, and polymorphisms that alter expression of this gene may play a role in carcinogenesis. Multiple transcript variants encoding different isoforms have been found for this gene. The last exon of this gene overlaps with the CD3e molecule, epsilon associated protein gene on the opposite strand. [provided by RefSeq, Oct 2009]

0.01 mg

610 USD