protein

Recombinant Human BAD

MBS143012

0.002 mg

265 USD

Recombinant Protein

Recombinant Human BAD

BAD

BAD Protein Human; BAD Protein Human Recombinant; Bcl2 antagonist of cell death; BAD; Bcl-2-binding component 6; Bcl-XL/Bcl-2-associated death promoter; Bcl-2-like 8 protein; BAD Protein; BBC6; BCL2L8

bcl2 antagonist of cell death; Bcl2-associated agonist of cell death; bcl2-associated agonist of cell death; BCL-X/BCL-2 binding protein; BCL2-antagonist of cell death protein; BCL2-binding component 6; BCL2-binding protein; bcl-2-binding component 6; bcl-2-like protein 8; bcl-XL/Bcl-2-associated death promoter; bcl2 antagonist of cell death; bcl2-L-8; BCL2-associated agonist of cell death; Bcl-2-binding component 6; Bcl-2-like protein 8; Bcl2-L-8; Bcl-xL/Bcl-2-associated death promoter; Bcl2 antagonist of cell death

BAD

BAD; BAD; BBC2; BCL2L8; BBC6; BCL2L8; BAD; Bcl2-L-8

BAD_HUMAN

E Coli

168

BAD protein at 100ug/ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol. Sterile Filtered clear solution.

Store vial at -20 degree C to -80 degree C. When stored at the recommended temperature, this protein is stable for 12 months.Please prevent freeze-thaw cycles.

ELISA (EIA), Western Blot (WB)

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins

Description: Bcl2 antagonist of cell death (BAD) Human Recombinant full length protein expressed in E Coli, shows a 51 kDa band on SDS-PAGE(Icluding GST tag). The BAD protein is purified by proprietary chromatographic techniques. Introduction: The Bcl-2 family of protein is characterized by its ability to modulate cell death under a broad range of physiologic conditions. Bcl-2 and several related proteins function to inhibit apoptosis while other members of the Bcl-2 family, such as Bax and Bak, enhance cell death under various conditions. Bad exhibits homology to Bcl-2 limited to the BH1, but not with Bax, Bcl-xS, Mcl-1, A1 or itself. In mammalian cells, Bad binds with greater affinity to Bcl-xL than to Bcl-2 and reverses the death repressor activity of Bcl-xL but not Bcl-2.

10835069

NP_004313.1

NM_004322.3

Q92934

18,392 Da

AKT Phosphorylates Targets In The Cytosol Pathway (106475); Activation Of BAD And Translocation To Mitochondria Pathway (105659); Activation Of BH3-only Proteins Pathway (105658); Acute Myeloid Leukemia Pathway (83117); Acute Myeloid Leukemia Pathway (529); Adaptive Immune System Pathway (366160); Alpha-synuclein Signaling Pathway (137913); Alpha6-Beta4 Integrin Signaling Pathway (198807); Alzheimer's Disease Pathway (83097); Alzheimer's Disease Pathway (509)

The protein encoded by this gene is a member of the BCL-2 family. BCL-2 family members are known to be regulators of programmed cell death. This protein positively regulates cell apoptosis by forming heterodimers with BCL-xL and BCL-2, and reversing their death repressor activity. Proapoptotic activity of this protein is regulated through its phosphorylation. Protein kinases AKT and MAP kinase, as well as protein phosphatase calcineurin were found to be involved in the regulation of this protein. Alternative splicing of this gene results in two transcript variants which encode the same isoform. [provided by RefSeq, Jul 2008]

BAD: a proapoptotic member of the Bcl-2 family. Displaces Bax from binding to Bcl-2 and Bcl-xL, resulting in cell death. Survival factors such as IL-3 can inhibit the apoptotic activity of Bad inducing the phosphorylation of Bad by Akt and p90RSK. 14-3-3 proteins bind phosphorylated Bad, inhibiting its binding to Bcl-2 and Bcl-xL. Phosphorylation by mitochondria-anchored PKA in the BH3 domain can block the dimerization of Bad and Bcl-xL. Protein type: Apoptosis. Chromosomal Location of Human Ortholog: 11q13.1. Cellular Component: mitochondrial outer membrane; mitochondrion; cytosol. Molecular Function: protein kinase B binding; protein binding; protein heterodimerization activity; phospholipid binding; caspase activator activity; lipid binding; protein kinase binding; protein phosphatase 2B binding. Biological Process: response to oleate; nerve growth factor receptor signaling pathway; apoptosis; positive regulation of proteolysis; positive regulation of apoptosis; response to glucocorticoid stimulus; positive regulation of caspase activity; cellular process regulating host cell cycle in response to virus; glucose homeostasis; response to estradiol stimulus; positive regulation of apoptosis by virus; response to glucose stimulus; pore complex biogenesis; positive regulation of autophagy; positive regulation of glucokinase activity; epidermal growth factor receptor signaling pathway; response to drug; caspase activation; release of cytochrome c from mitochondria; phosphoinositide-mediated signaling; fibroblast growth factor receptor signaling pathway; cytokine and chemokine mediated signaling pathway; suppression by virus of host apoptosis; positive regulation of insulin secretion; ADP metabolic process; response to testosterone stimulus; response to amino acid stimulus; ATP metabolic process; glucose catabolic process; response to ethanol; DNA damage response, signal transduction resulting in induction of apoptosis; positive regulation of T cell differentiation; response to hydrogen peroxide; induction of apoptosis via death domain receptors; innate immune response; positive regulation of B cell differentiation; regulation of mitochondrial membrane permeability; response to progesterone stimulus; response to calcium ion; positive regulation of epithelial cell proliferation

0.002 mg

265 USD

0.005 mg

365

0.01 mg

610