Recombinant Human Triggering Receptor Expressed on Myeloid Cells 1 | MyBioSource MBS143011 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Triggering Receptor Expressed on Myeloid Cells 1

catalog :

MBS143011

quantity :

0.002 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143011

products type :

Recombinant Protein

products full name :

Recombinant Human Triggering Receptor Expressed on Myeloid Cells 1

products short name :

Triggering Receptor Expressed on Myeloid Cells 1

products name syn :

TREM1 Human; Triggering Receptor Expressed on Myeloid Cells 1 Human Recombinant; Triggering receptor expressed on myeloid cells 1; Triggering receptor expressed on monocytes 1; TREM-1; TREM1

other names :

triggering receptor expressed on myeloid cells 1 isoform 2; Triggering receptor expressed on myeloid cells 1; triggering receptor expressed on myeloid cells 1; triggering receptor expressed on monocytes 1; triggering-receptor TREM1; triggering receptor expressed on myeloid cells 1; Triggering receptor expressed on monocytes 1; CD_antigen: CD354

products gene name :

TREM1

other gene names :

TREM1; TREM1; CD354; TREM-1; TREM-1

uniprot entry name :

TREM1_HUMAN

host :

E Coli

sequence length :

225

purity :

Greater than 95.0% as determined by SDS-PAGE.

form :

TREM1 protein (0.25mg/ml) is supplied in 10mM Tris-HCl pH-8, 62.5mM NaCl and 50% glycerol. Sterile Filtered clear solution.

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. Please avoid freeze thaw cycles.

products categories :

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins

products description :

Description: TREM1 Human Recombinant produced in E Coli is single, a non-glycosylated, Polypeptide chain containing 180 amino acids fragment (21-200) corresponding to mature soluble extracellular domain fragment of TREM-1, having a total molecular mass of 24.76kDa and fused with a 4.5kDa amino-terminal hexahistidine tag. The TREM1 is purified by proprietary chromatographic techniques. Introduction: TREM1 is a transmembrane receptor protein that is involved in monocytic activation and in the inflammatory response. TREM1 is expressed on the surface of neutrophils, mature monocytes and macrophages. TREM1 stimulates neutrophil and monocyte-mediated inflammatory responses. TREM1 also triggers the release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Furthermore, TREM1 is an amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a fundamental mediator of septic shock. The expression of the soluble form of TREM1 increases during sepsis and can consequently be used as a biological marker for septic shock. TREM1 is strongly expressed in acute inflammatory lesions caused by bacteria and fungi. Increased TREM1 expression on monocytes is related to both infectious and noninfectious inflammatory processes.TREM1 is vastly expressed in adult liver, lung and spleen than in corresponding fetal tissue. TREM1 is also expressed in the lymph node, placenta, spinal cord and heart tissues. TREM1 expression is more elevated in peripheral blood leukocytes than in the bone marrow and in normal cells than malignant cells. TREM1 is expressed at low levels in the early development of the hematopoietic system and in the promonocytic stage and at high levels in mature monocytes.

ncbi gi num :

336088680

ncbi acc num :

NP_001229518.1

ncbi gb acc num :

NM_001242589.1

uniprot acc num :

Q9NP99

ncbi mol weight :

25,574 Da

ncbi pathways :

Cell Surface Interactions At The Vascular Wall Pathway (106062); DAP12 Interactions Pathway (685549); Hemostasis Pathway (106028); Immune System Pathway (106386); Innate Immune System Pathway (106387)

ncbi summary :

This gene encodes a receptor belonging to the Ig superfamily that is expressed on myeloid cells. This protein amplifies neutrophil and monocyte-mediated inflammatory responses triggered by bacterial and fungal infections by stimulating release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene.[provided by RefSeq, Jun 2011]

uniprot summary :

TREM1: Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 6p21.1. Cellular Component: integral to membrane; extracellular region; plasma membrane. Molecular Function: receptor activity. Biological Process: neutrophil chemotaxis; innate immune response; cytokine secretion during immune response; blood coagulation; chemokine metabolic process; leukocyte migration; humoral immune response

size1 :

0.002 mg

price1 :

140 USD

size2 :

0.01 mg

price2 :

205

size3 :

1 mg

price3 :

4630

more info or order :

MyBioSource product webpage