Recombinant Human Autophagy Related 5 | MyBioSource MBS143008 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Autophagy Related 5

catalog :

MBS143008

quantity :

0.002 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS143008

products type :

Recombinant Protein

products full name :

Recombinant Human Autophagy Related 5

products short name :

Autophagy Related 5

products name syn :

ATG5 Human; Autophagy Related 5 Human Recombinant; Autophagy protein 5; APG5-like; Apoptosis-specific protein; ATG5; ASP; APG5; APG5L; hAPG5

other names :

autophagy protein 5 isoform a; Autophagy protein 5; autophagy protein 5; ATG5 autophagy related 5 homolog; apoptosis-specific protein; autophagy related 5; APG5-like; Apoptosis-specific protein

products gene name :

ATG5

other gene names :

ATG5; ATG5; ASP; APG5; APG5L; hAPG5; APG5-LIKE; APG5L; ASP

uniprot entry name :

ATG5_HUMAN

host :

E Coli

sequence length :

275

sequence :

MGSSHHHHHH SSGLVPRGSH MTDDKDVLRD VWFGRIPTCF TLYQDEITER EAEPYYLLLPRVSYLTLVTD KVKKHFQKVM RQEDISEIWF EYEGTPLKWH YPIGLLFDLL ASSSALPWNITVHFKSFPEK DLLHCPSKDA IEAHFMSCMK EADALKHKSQ VINEMQKKDH KQLWMGLQND RFDQFWAINR KLMEYPAEEN GFRYIPFRIY QTTTERPFIQ KLFRPVAADG QLHTLGDLLKEVCPSAIDPE DGEKKNQVMI HGIEPMLETP LQWLSEHLSY PDNFLHISII PQPTD

purity :

Greater than 85.0% as determined by SDS-PAGE.

form :

ATG5 at a concentration of 0.25mg/ml containing 20mM Tris-HCl, pH 8.0, 1mM DTT, 0.2M NaCl and 40% glycerol. Sterile Filtered clear solution.

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

products categories :

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Autophagy Related

products description :

Description: ATG5 produced in E Coli is a single, non-glycosylated polypeptide chain containing 295 amino acids (1-275a.a.) and having a molecular mass of 34.6kDa.ATG5 is fused to a 20 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Introduction: ATG5 is a member of the autophagy-related (ATG) genes family. Autophagy is a catabolic process for the autophagosomic-lysosomal degradation of bulk cytoplasmic contents. ATG5 protein is essential for autophagy. It conjugates to ATG12 and associates with isolation membrane to form autophagosomes. In addition ATG5 takes a vital part in the apoptotic process and it is expressed relatively late in the apoptotic process, downstream of caspase activity.

ncbi gi num :

554790362

ncbi acc num :

NP_001273035.1

ncbi gb acc num :

NM_001286106.1

uniprot acc num :

Q9H1Y0

ncbi mol weight :

22,931 Da

ncbi pathways :

Immune System Pathway (106386); Innate Immune System Pathway (106387); Negative Regulators Of RIG-I/MDA5 Signaling Pathway (187102); RIG-I-like Receptor Signaling Pathway (117292); RIG-I-like Receptor Signaling Pathway (116128); RIG-I/MDA5 Mediated Induction Of IFN-alpha/beta Pathways (187097); Regulation Of Autophagy Pathway (83058); Regulation Of Autophagy Pathway (468); Senescence And Autophagy Pathway (198780); Shigellosis Pathway (83104)

uniprot summary :

ATG5: Required for autophagy. Conjugates to ATG12 and associates with isolation membrane to form cup-shaped isolation membrane and autophagosome. The conjugate detaches from the membrane immediately before or after autophagosome formation is completed. The ATG5-ATG12 conjugate forms a complex with several units of ATG16. Interacts with TECPR1; the interaction is direct and does not take place when ATG16 is associated with the ATG5- ATG12 conjugate. By apoptotic stimuli. Ubiquitous. The mRNA is present at similar levels in viable and apoptotic cells, whereas the protein is dramatically highly expressed in apoptotic cells. Belongs to the ATG5 family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Autophagy; Apoptosis; Ubiquitin conjugating system. Chromosomal Location of Human Ortholog: 6q21. Cellular Component: membrane; cytoplasm; pre-autophagosomal structure membrane; autophagic vacuole; axoneme. Molecular Function: protein binding; APG8 conjugating enzyme activity. Biological Process: response to drug; response to fungus; apoptosis; ventricular cardiac muscle cell development; C-terminal protein lipidation; post-translational protein modification; vasodilation; regulation of release of sequestered calcium ion into cytosol; cellular response to nitrogen starvation; heart contraction; regulation of cytokine secretion during immune response; mitochondrion degradation; autophagy; innate immune response; negative regulation of protein ubiquitination; blood vessel remodeling; negative regulation of interferon type I production; otolith development; negative regulation of apoptosis; autophagic vacuole formation

size1 :

0.002 mg

price1 :

140 USD

size2 :

0.01 mg

price2 :

205

size3 :

1 mg

price3 :

5015

more info or order :

MyBioSource product webpage