protein

Recombinant Human Annexin A7

MBS143003

0.005 mg

140 USD

Recombinant Protein

Recombinant Human Annexin A7

Annexin A7

ANXA7 Human; Annexin A7 Human Recombinant; Annexin A7; Annexin-7; Annexin VII; Synexin; ANXA7; ANX7; SNX

annexin A7 isoform 1; Annexin A7; annexin A7; annexin VII; annexin-7; annexin A7; Annexin VII; Annexin-7; Synexin

ANXA7

ANXA7; ANXA7; SNX; ANX7; SYNEXIN; ANX7; SNX

ANXA7_HUMAN

E Coli

466

Greater than 85.0% as determined by SDS-PAGE.

ANXA7 protein solution (0.25mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 150mM NaCl, 1mM DTT and 40% glycerol. Sterile Filtered clear solution.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Annexin

Description: ANXA7 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 490 amino acids (1-466 a.a.) and having a molecular mass of 52.9kDa.ANXA7 is fused to a 24 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Introduction: Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins. Annexin VII has molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of 299 amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties including voltage-sensitive calcium channel activity, ion selectivity and membrane fusion.

4502111

NP_001147.1

NM_001156.3

P20073

50,316 Da

Annexin VII is a member of the annexin family of calcium-dependent phospholipid binding proteins.The Annexin VII gene contains 14 exons and spans approximately 34 kb of DNA. An alternatively spliced cassette exon results in two mRNA transcripts of 2.0 and 2.4 kb which are predicted to generate two protein isoforms differing in their N-terminal domain. The alternative splicing event is tissue specific and the mRNA containing the cassette exon is prevalent in brain, heart and skeletal muscle. The transcripts also differ in their 3'-non coding regions by the use of two alternative poly(A) signals. Annexin VII encodes a protein with a molecular weight of approximately 51 kDa with a unique, highly hydrophobic N-terminal domain of 167 amino acids and a conserved C-terminal region of 299 amino acids. The latter domain is composed of alternating hydrophobic and hydrophilic segments. Structural analysis of the protein suggests that Annexin VII is a membrane binding protein with diverse properties, including voltage-sensitive calcium channel activity, ion selectivity and membrane fusion. [provided by RefSeq, Jul 2008]

ANXA7: Calcium/phospholipid-binding protein which promotes membrane fusion and is involved in exocytosis. Interacts with PDCD6. Isoform 1 is expressed in brain, heart and skeletal muscle. Isoform 2 is more abundant in liver, lung, kidney, spleen, fibroblasts and placenta. Belongs to the annexin family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; Calcium-binding; Lipid-binding. Chromosomal Location of Human Ortholog: 10q22.2. Cellular Component: endoplasmic reticulum membrane; membrane; plasma membrane; nuclear envelope; nucleus; cytosol. Molecular Function: integrin binding; protein binding; calcium-dependent phospholipid binding; calcium ion binding; calcium-dependent protein binding. Biological Process: cellular calcium ion homeostasis; regulation of cell shape; cell proliferation; cellular water homeostasis; epithelial cell differentiation; hemostasis; autophagy; social behavior; response to calcium ion; response to organic cyclic substance; response to salt stress

0.005 mg

140 USD

0.02 mg

205

1 mg

2665