protein

Human Thyroglobulin

MBS142997

0.02 mg

140 USD

Native Protein

Human Thyroglobulin

Thyroglobulin

Thyroglobulin Human; Thyroglobulin Human; Thyroglobulin; TGN; AITD3; TG; Thyroglobulin

thyroglobulin; Thyroglobulin; thyroglobulin; thyroglobulin

TG; TG; TGN; AITD3; Tg

THYG_HUMAN

Native, Isolated from human thyroid glands

2768

Greater than 95% as determined by SDS-PAGE.

Human Thyroglobulin is supplied in 16mM HEPES buffer pH-7.6, 240mM sodium chloride, and 20% glycerol. Sterile Filtered solution.

Coating Concentration: 0.7-1 ug/ml (depending on the type of ELISA plate and coating buffer).Suitable for biotinylation and iodination.

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. Avoid multiple freeze-thaw cycles.

RECOMBINANT & NATURAL PROTEINS; Natural Proteins

Description: Human Thyroglobulin is a glycosylated, polypeptide chain having a total molecular mass of 662 kDa (331 kDa per subunit). Introduction: Thyroglobulin (TG) represents one of the main autoantigenic targets in autoimmune thyroid disease of humans. TG is a large globular dimeric glycoprotein with a total molecular weight of 660 kDa, which occupies a key precursor role in the biosynthesis of the thyroid hormones. Approximately 75% of the total protein content of the thyroid follicle consists of TG. The thyroid gland uses the Thyroglobulin in order to produce the thyroid hormones thyroxine (T4) and triiodothyronine (T3). Thyroglobulin is produced by the thyroid epithelial cells (thyrocytes) which form spherical follicles. Thyroglobulin is subsequently secreted and stored in the follicular lumen.Patients with Hashimoto's thyroiditis or Graves' disease, frequently develop antibodies against Thyroglobulin. Tg-specific antibodies help in the diagnosis of the above diseases, however they also may be present in apparently healthy euthyroid individuals. Blood Thyroglobulin levels can be used as a tumor marker for certain kinds of thyroid cancer, and the may also be elevated in cases of Graves' disease.

55770862

NP_003226.4

NM_003235.4

P01266

298,383 Da

Autoimmune Thyroid Disease Pathway 83121!!Autoimmune Thyroid Disease Pathway 533!!Thyroid Hormone Synthesis Pathway 835410!!Thyroid Hormone Synthesis Pathway 839541!!Thyroxine (Thyroid Hormone) Production Pathway 920992

Thyroglobulin (Tg) is a glycoprotein homodimer produced predominantly by the thryroid gland. It acts as a substrate for the synthesis of thyroxine and triiodothyronine as well as the storage of the inactive forms of thyroid hormone and iodine. Thyroglobulin is secreted from the endoplasmic reticulum to its site of iodination, and subsequent thyroxine biosynthesis, in the follicular lumen. Mutations in this gene cause thyroid dyshormonogenesis, manifested as goiter, and are associated with moderate to severe congenital hypothyroidism. Polymorphisms in this gene are associated with susceptibility to autoimmune thyroid diseases (AITD) such as Graves disease and Hashimoto thryoiditis. [provided by RefSeq, Nov 2009]

0.02 mg

140 USD