Recombinant Human Recoverin | MyBioSource MBS142995 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Recoverin

catalog :

MBS142995

quantity :

0.01 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142995

products type :

Recombinant Protein

products full name :

Recombinant Human Recoverin

products short name :

Recoverin

products name syn :

Recoverin Human; Recoverin Human Recombinant; RCV1; Cancer-associated retinopathy protein; Protein CAR; RCVRN; Recoverin

other names :

recoverin; Recoverin; recoverin; cancer associated retinopathy antigen; cancer-associated retinopathy protein; recoverin; Cancer-associated retinopathy protein; Protein CAR

products gene name :

RCVRN

other gene names :

RCVRN; RCVRN; RCV1; RCV1; Protein CAR

uniprot entry name :

RECO_HUMAN

host :

E Coli

sequence length :

200

sequence :

MGNSKSGALS KEILEELQLN TKFSEEELCS WYQSFLKDCP TGRITQQQFQ SIYAKFFPDT DPKAYAQHVF RSFDSNLDGT LDFKEYVIAL HMTTAGKTNQ KLEWAFSLYD VDGNGTISKNEVLEIVMAIF KMITPEDVKL LPDDENTPEK RAEKIWKYFG KNDDDKLTEK EFIEGTLANK EILRLIQFEP QKVKEKMKNA.

purity :

Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

form :

The protein (1mg/ml) contains 20mM Tris-HCI pH 8.0, 1mM EDTA, 2mM MgCl2 and 10% Glycerol. Sterile filtered colorless solution.

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

products categories :

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins

products description :

Description: Recoverin Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 200 amino acids & having a molecular mass of 23kDa. Introduction: Recoverin is a member of the recoverin family of neuronal calcium sensors. Recoverin is a heterogeneously acylated calcium-binding and intracellular signal transduction 23kDa protein in the photoreceptor cells of retina. Recoverin contains four EF-hands, of which two bind Ca. Ca-induced extrusion of the acyl group from a hydrophobic cleft in the protein drives the translocation of recoverin from solution to the disc membrane. Recoverin may prolong the termination of the phototransduction cascade in the retina by blocking the phosphorylation of photo-activated rhodopsin. Recoverin plays a key role in the inhibition of rhodopsin kinase, a molecule that regulates the phosphorylation of rhodopsin. This in due course controls the ability of the eye to adapt to, and recover from, exposure to the presence of light. Recoverin is a detectable serologic protein that is expressed in patients with cancer-associated retinopathy, a paraneoplastic syndrome.

ncbi gi num :

4506459

ncbi acc num :

NP_002894.1

ncbi gb acc num :

NM_002903.2

uniprot acc num :

P35243

ncbi mol weight :

23,130 Da

ncbi pathways :

Disease Pathway (530764); Diseases Associated With Visual Transduction Pathway (771581); Inactivation, Recovery And Regulation Of The Phototransduction Cascade Pathway (833795); Phototransduction Pathway (149806); Phototransduction Pathway (148660); Signal Transduction Pathway (477114); The Phototransduction Cascade Pathway (833793); Visual Phototransduction Pathway (771584)

ncbi summary :

This gene encodes a member of the recoverin family of neuronal calcium sensors. The encoded protein contains three calcium-binding EF-hand domains and may prolong the termination of the phototransduction cascade in the retina by blocking the phosphorylation of photo-activated rhodopsin. Recoverin may be the antigen responsible for cancer-associated retinopathy. [provided by RefSeq, Jul 2008]

uniprot summary :

RCV1: Seems to be implicated in the pathway from retinal rod guanylate cyclase to rhodopsin. May be involved in the inhibition of the phosphorylation of rhodopsin in a calcium-dependent manner. The calcium-bound recoverin prolongs the photoresponse. Belongs to the recoverin family. Protein type: Calcium-binding. Chromosomal Location of Human Ortholog: 17p13.1. Cellular Component: dendrite. Molecular Function: calcium sensitive guanylate cyclase activator activity; calcium ion binding. Biological Process: rhodopsin mediated signaling; phototransduction, visible light; regulation of rhodopsin mediated signaling; visual perception; positive regulation of guanylate cyclase activity; regulation of calcium ion transport; signal transduction

size1 :

0.01 mg

price1 :

140 USD

size2 :

0.05 mg

price2 :

205

size3 :

1 mg

price3 :

2460

more info or order :

MyBioSource product webpage