catalog number :
MBS142988
products type :
Recombinant Protein
products full name :
Recombinant Human CCAAT/enhancer binding protein(C/EBP) Gamma
products short name :
CCAAT/enhancer binding protein(C/EBP) Gamma
products name syn :
CEBP Gamma Human; CCAAT/enhancer binding protein C/EBP Gamma Recombinant Human; CCAAT/enhancer-binding protein gamma; C/EBP gamma; CEBPG; GPE1BP; IG/EBP-1
other names :
CCAAT/enhancer-binding protein gamma; CCAAT/enhancer-binding protein gamma; CCAAT/enhancer-binding protein gamma; c/EBP gamma; CCAAT/enhancer binding protein (C/EBP), gamma
products gene name :
CEBP-g
other gene names :
CEBPG; CEBPG; GPE1BP; IG/EBP-1; C/EBP gamma
uniprot entry name :
CEBPG_HUMAN
sequence :
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSMPGG GGKAVAPSKQ SKKSSPMDRN SDEYRQRRER NNMAVKKSRL KSKQKAQDTL QRVNQLKEEN ERLEAKIKLL TKELSVLKDL FLEHAHNLAD NVQSISTENT TADGDN.
purity :
Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
form :
The protein contains 20mM Tris-HCl pH7.5, 0.1M NaCl and 5mM b-Mercaptoethanol. Sterile filtered colorless solution.
storage stability :
Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
products categories :
RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; CCAAT/enhancer binding protein
products description :
Description: CEBP-g Recombinant Human His-Tag fusion protein produced in E Coli is a single, non-glycosylated polypeptide chain containing amino acids 146 (aa 39-147) and having a molecular mass of 16.5 kDa. The DNA binding domain of CEBP-g was purified by proprietary chromatographic techniques. Introduction: CCAAT/enhancer binding protein(C/EBP) g is a family of transcription factors all contain a highly conserved, basic-leucine zipper domain at the C-terminus that is involved in dimerization and DNA binding. C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP family consist of several related proteins, C/EBP a,b,g,d, that form homodimers and/or form heterodimers with each other. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein; a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. C/EBP g may cooperate with Fos to bind PRE- enhancer elements.
ncbi acc num :
NP_001239225.1
ncbi gb acc num :
NM_001252296.1
ncbi mol weight :
16,408 Da
ncbi pathways :
Tuberculosis Pathway (213780); Tuberculosis Pathway (213743)
ncbi summary :
The C/EBP family of transcription factors regulates viral and cellular CCAAT/enhancer element-mediated transcription. C/EBP proteins contain the bZIP region, which is characterized by two motifs in the C-terminal half of the protein: a basic region involved in DNA binding and a leucine zipper motif involved in dimerization. The C/EBP family consist of several related proteins, C/EBP alpha, C/EBP beta, C/EBP gamma, and C/EBP delta, that form homodimers and that form heterodimers with each other. CCAAT/enhancer binding protein gamma may cooperate with Fos to bind PRE-I enhancer elements. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Nov 2011]
uniprot summary :
C/EBP-gamma: Transcription factor that binds to the enhancer element PRE-I (positive regulatory element-I) of the IL-4 gene. Might change the DNA-binding specificity of other transcription factors and recruit them to unusual DNA sites. Belongs to the bZIP family. C/EBP subfamily. Protein type: DNA-binding; Transcription factor; Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 19q13.11. Cellular Component: nucleoplasm; nucleus. Molecular Function: protein binding; DNA binding; protein heterodimerization activity; sequence-specific DNA binding; double-stranded DNA binding; transcription factor binding. Biological Process: positive regulation of DNA repair; transcription, DNA-dependent; natural killer cell mediated cytotoxicity; negative regulation of transcription factor activity; enucleate erythrocyte differentiation; liver development; mRNA metabolic process; regulation of transcription from RNA polymerase II promoter; B cell differentiation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; immune response; positive regulation of DNA binding; positive regulation of interferon-gamma biosynthetic process