Recombinant Human Natural Cytotoxicity Receptor NKp46 | MyBioSource MBS142986 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Natural Cytotoxicity Receptor NKp46

catalog :

MBS142986

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142986

products type :

Recombinant Protein

products full name :

Recombinant Human Natural Cytotoxicity Receptor NKp46

products short name :

Natural Cytotoxicity Receptor NKp46

products name syn :

NKp46 Human; Natural Cytotoxicity Receptor NKp46 Human Recombinant; Natural cytotoxicity triggering receptor 1; Natural killer cell p46-related protein; hNKp46; NK-p46; NKp46; NK cell-activating receptor; Lymphocyte antigen 94 homolog; CD335 antigen; NCR1; LY94; NCRNKp46; CD335

other names :

natural cytotoxicity triggering receptor 1 isoform b; Natural cytotoxicity triggering receptor 1; natural cytotoxicity triggering receptor 1; NK cell-activating receptor; lymphocyte antigen 94 homolog (activating NK-receptor; NK-p46); natural killer cell p46-related protein; natural cytotoxicity triggering receptor 1; Lymphocyte antigen 94 homolog; NK cell-activating receptor; Natural killer cell p46-related protein; NK-p46; NKp46; hNKp46; CD_antigen: CD335

products gene name :

NKp46

other gene names :

NCR1; NCR1; LY94; CD335; NKP46; NK-p46; LY94; NK-p46; NKp46; hNKp46

uniprot entry name :

NCTR1_HUMAN

host :

E Coli

sequence length :

303

sequence :

MQQQTLPKPF IWAEPHFMVP KEKQVTICCQ GNYGAVEYQL HFEGSLFAVD RPKPPERINKVKFYIPDMNS RMAGQYSCIY RVGELWSEPS NLLDLVVTEM YDTPTLSVHP GPEVISGEEV TFYCRLDTAT SMFLLLKEGR SSHVQRGYGK VQAEFPLGPV TTAHRGTYRX FGSYNNHAWSFPSEPVKLLV TGDIENTSLA PEDPTFSADT WGTYLLTTET GLQKDHALWD HTAQN.

purity :

Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

form :

The protein contains phosphate buffered saline (pH7.4) & 1mM EDTA. Sterile filtered colorless solution.

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

products categories :

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins

products description :

Description: NKp46 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 235 amino acids and having a molecular mass of 26.6 kDa. Introduction: A natural cytotoxicity receptor (NCR) NKp46 has been shown to represent a novel NK cell-specific molecule involved in human NK cell activation. The natural cytotoxicity receptors (NCRs) are a recently characterized family of Ig-like activation receptors that appear to be major triggering receptors in tumor cell recognition. The three known NCRs include NKp46 and NKp30, which are expressed on circulating NKcells, and NKp44, which is expressed only on activating NK cells. NKp46 has been implicated in NK cell-mediated lysis of several autologous tumor cells, pathogen-infected cell lines and mononuclear phagocytes infected with an intracellular bacterium. The Lysis of tumor cells by NK-cells involves recognition by NKp46 of heparan sulfate moieties of membrane heparan sulfate proteoglycans. Furthermore, NKp46 is a surface receptor involved in NK-cell cell death by apoptosis. NKp46 has two extracellular Ig-like domains followed by a ~40 residue stalk region, a type I transmembrane domain, and a short cytoplasmic tail. The extracellular Ig-like domain of NKp46 (22-255aa) is purified by FPLC gel-filtration chromatography, after refolding of the isolated inclusion bodies in a redox buffer. In addition, engagement of the antigen with the monoclonal antibody stimulates intracellular calcium levels and the synthesis of cytokines. CD59 is an NKp46 coreceptor (by physical association) together they activate cytotoxicity of human NK-cells, their engagement results in tyrosine phosphorylation of CD3-zeta chains associated with NKp46. Reduced cell surface expression of NKp46 and other NK-cell receptors is linked to the impaired NK-cell cytolytic function in viremic HIV-1 infection.

ncbi gi num :

523498722

ncbi acc num :

NP_001138929.2

ncbi gb acc num :

NM_001145457.2

uniprot acc num :

O76036

ncbi mol weight :

34,409 Da

ncbi pathways :

Natural Killer Cell Mediated Cytotoxicity Pathway (83079); Natural Killer Cell Mediated Cytotoxicity Pathway (490)

uniprot summary :

NCR1: Cytotoxicity-activating receptor that may contribute to the increased efficiency of activated natural killer (NK) cells to mediate tumor cell lysis. Belongs to the natural cytotoxicity receptor (NCR) family. 6 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Receptor, misc.; Apoptosis. Chromosomal Location of Human Ortholog: 19q13.42. Cellular Component: SWI/SNF complex; integral to plasma membrane. Molecular Function: receptor signaling protein activity. Biological Process: regulation of natural killer cell mediated cytotoxicity; cellular defense response; natural killer cell activation; signal transduction

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

1 mg

price3 :

2750

more info or order :

MyBioSource product webpage