Recombinant Human Leukocyte-Associated Ig-Like Receptor 1 | MyBioSource MBS142985 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Leukocyte-Associated Ig-Like Receptor 1

catalog :

MBS142985

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142985

products type :

Recombinant Protein

products full name :

Recombinant Human Leukocyte-Associated Ig-Like Receptor 1

products short name :

Leukocyte-Associated Ig-Like Receptor 1

products name syn :

LAIR1 Human; Leukocyte-Associated Ig-Like Receptor 1 Human Recombinant; Leukocyte-associated immunoglobulin-like receptor 1; LAIR-1; hLAIR1; CD305 antigen; LAIR1; CD305

other names :

leukocyte-associated immunoglobulin-like receptor 1 isoform c; Leukocyte-associated immunoglobulin-like receptor 1; leukocyte-associated immunoglobulin-like receptor 1; leukocyte-associated Ig-like receptor 1; leukocyte-associated immunoglobulin-like receptor 1; CD_antigen: CD305

products gene name :

LAIR1

other gene names :

LAIR1; LAIR1; CD305; LAIR-1; CD305; LAIR-1; hLAIR1

uniprot entry name :

LAIR1_HUMAN

host :

E Coli

sequence length :

269

sequence :

MQEEDLPRPS ISAEPGTVIP LGSHVTFVCR GPVGVQTFRL ERESRSTYND TEDVSQASPSESEARFRIDS VSEGNAGPYR CIYYKPPKWS EQSDYLELLV KETSG.

purity :

Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

form :

The protein (1mg/ml) contains 20mM Tris-HCl (pH7.5) 50mM NaCl and 1mM EDTA. Sterile filtered colorless solution.

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks.Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

products categories :

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Leukocyte-Associated Ig-Like Receptor

products description :

Description: LAIR1 Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing amino acids 105 and having a molecular mass of 11.5 kDa. The extracellular domain of LAIR-1 (22-125aa) was overexpressed in E Coli, and purified by using conventional chromatography techniques. Introduction: LAIR1 is a glycoprotein (~32kDa) expressed on the surface of the majority of human peripheral blood mononuclear leukocytes including T cells, B cells, NK cells, macrophages and dendritic cells. LAIR-1 functions as an inhibitory receptor in NK cells, T cells and B cells. Inhibitory receptors control the immune response to prevent lysis of cells recognized as self. Lair1 consists of a leader sequence, extracellular domain, transmembrane domain, cytoplasmic region. LAIR1 is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. LAIR1 maps to a region of 19q13.4 labeled the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily.

ncbi gi num :

612407867

ncbi acc num :

NP_001275952.2

ncbi gb acc num :

NM_001289023.2

uniprot acc num :

Q6GTX8

ncbi mol weight :

23,049 Da

ncbi summary :

The protein encoded by this gene is an inhibitory receptor found on peripheral mononuclear cells, including natural killer cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region of 19q13.4 called the leukocyte receptor cluster, which contains at least 29 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. The encoded protein has been identified as an anchor for tyrosine phosphatase SHP-1, and may induce cell death in myeloid leukemias. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2014]

uniprot summary :

LAIR-1: an inhibitory receptor found on peripheral mononuclear cells, including NK cells, T cells, and B cells. Inhibitory receptors regulate the immune response to prevent lysis of cells recognized as self. The gene is a member of both the immunoglobulin superfamily and the leukocyte-associated inhibitory receptor family. The gene maps to a region called the leukocyte receptor cluster, which contains at least 25 genes encoding leukocyte-expressed receptors of the immunoglobulin superfamily. Protein type: Membrane protein, integral; Receptor, misc. Chromosomal Location of Human Ortholog: 19q13.4. Cellular Component: plasma membrane; integral to membrane. Molecular Function: protein binding. Biological Process: immune system process

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

1 mg

price3 :

2750

more info or order :

MyBioSource product webpage