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Recombinant Human Killer Cell Immunoglobulin-Like Receptor, 2 Domains Short Cytoplasmic Tail 4

MBS142984

0.02 mg

205 USD

MBS142984

Recombinant Protein

Recombinant Human Killer Cell Immunoglobulin-Like Receptor, 2 Domains Short Cytoplasmic Tail 4

Killer Cell Immunoglobulin-Like Receptor

KIR2DS4 Human; Killer Cell Immunoglobulin-Like Receptor, 2 Domains Short Cytoplasmic Tail, 4 Recombinant Human; Killer cell immunoglobulin-like receptor 2DS4; MHC class I NK cell receptor; Natural killer-associated transcript 8; NKAT-8; P58 natural killer cell receptor clone CL-39; p58 NK receptor; CL-17; CD158 antigen-like family member I; CD158i antigen; KIR2DS4; CD158I; KKA3; NKAT8; KIR1D; KIR412; MGC120019; MGC125315; MGC125317

killer cell immunoglobulin-like receptor 2DS4 isoform 2; Killer cell immunoglobulin-like receptor 2DS4; killer cell immunoglobulin-like receptor 2DS4; CD158 antigen-like family member I; KIR antigen 2DS4; MHC class I NK cell receptor; P58 natural killer cell receptor clones CL-39/CL-17; killer Ig receptor; killer cell immunoglobulin-like receptor two domains short cytoplasmic tail 1; killer inhibitory receptor 4-1-2; natural killer cell inhibitory receptor; natural killer-associated transcript 8; p58 NK receptor CL-39/CL-17; killer cell immunoglobulin-like receptor, two domains, short cytoplasmic tail, 4; CD158 antigen-like family member I; MHC class I NK cell receptor; Natural killer-associated transcript 8; NKAT-8; P58 natural killer cell receptor clones CL-39/CL-17; p58 NK receptor CL-39/CL-17; CD_antigen: CD158i

KIR2DS4

KIR2DS4; KIR2DS4; KKA3; KIR1D; NKAT8; CD158I; KIR412; NKAT-8; KIR2DS1; CD158I; KKA3; NKAT8; NKAT-8; p58 NK receptor CL-39/CL-17

KI2S4_HUMAN

E Coli

239

MEGVHRKPSF LALPGHLVKS EETVILQCWS DVMFEHFLLH REGKFNNTLH LIGEHHDGVS KANFSIGPMM PVLAGTYRCY GSVPHSPYQL SAPSDPLDMV IIGLYEKPSL SAQPGPTVQA GENVTLSCSS RSSYDMYHLS REGEAHERRL PAVRSINGTF QADFPLGPAT HGGTYRCFGS FRDAPYEWSN SSDPLLVSVT GN.

Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

The protein (1mg/ml) contains 20mM Tris-HCl (pH-7.5). Sterile filtered colorless solution.

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Killer Cell

Description: Recombinant KIR2DS4 produced in E Coli is a single, non-glycosylated polypeptide chain containing amino acids 1-202 and having a molecular mass of 22.2 kDa. The KIR2DS4 is purified by proprietary chromatographic techniques. Introduction: Killer-cell immunoglobulin-like receptors (KIRs), are a family of cell surface glycoproteins found on Natural Killer (NK) Cells, which are important cells of the immune system. They control the killing function of these cells by interacting with MHC class I molecules, which are expressed on all cell types. This interaction allows them to identify virally infected cells or tumor cells that have a distinctive low level of Class I MHC on their surface. The majority of KIRs are inhibitory, which means that their recognition of MHC suppresses the cytotoxic activity of their NK cell. Only a limited number of KIRs have the capacity to activate cells. The KIR genes are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). KIR molecules are extremely polymorphic, meaning their gene sequences differ significantly between individuals, so that different individuals have different arrays/repertoires of KIR genes.The KIR proteins are categorized by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM). Whereas KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. KIR2DS4 is an activating Killer Cell Ig-like Receptor (KIR, previously called p50 KIR, p50.3, cl39, or KAR-K1), which may recognize class I MHC molecules. KIR2DS4 does not inhibit the activity of NK cells.

530353676

NP_001268900.1

NM_001281971.1

P43632

33,583 Da

Antigen Processing And Presentation Pathway 83074!!Antigen Processing And Presentation Pathway 485!!DAP12 Interactions Pathway 685549!!Immune System Pathway 106386!!Innate Immune System Pathway 106387!!Natural Killer Cell Mediated Cytotoxicity Pathway 83079!!Natural Killer Cell Mediated Cytotoxicity Pathway 490

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

0.02 mg

205 USD