protein

Recombinant Human Killer Cell Immunoglobulin-Like Receptor, 3 Domains Long Cytoplasmic Tail 1

MBS142981

0.005 mg

140 USD

Recombinant Protein

Recombinant Human Killer Cell Immunoglobulin-Like Receptor, 3 Domains Long Cytoplasmic Tail 1

Killer Cell Immunoglobulin-Like Receptor

KIR3DL1 Human; Killer Cell Immunoglobulin-Like Receptor, 3 Domains Long Cytoplasmic Tail 1 Human Recombinant; Killer cell immunoglobulin-like receptor 3DL1; MHC class I NK cell receptor; Natural killer-associated transcript 3; NKAT-3; p70 natural killer cell receptor clones CL-2/CL-11; HLA-BW4-specific inhibitory NK cell receptor; CD158 antigen-like family member E; CD158e antigen; KIR3DL1; CD158E; NKAT3; NKB1; KIR; NKB1B; CD158E1; MGC119726; MGC119728; MGC126589; MGC126591

killer cell immunoglobulin-like receptor 3DL1; Killer cell immunoglobulin-like receptor 3DL1; killer cell immunoglobulin-like receptor 3DL1; CD158 antigen-like family member E; HLA-BW4-specific inhibitory NK cell receptor; KIR antigen 3DL1; MHC class I NK cell receptor; NK-receptor; killer Ig receptor; natural killer-associated transcript 3; p70 NK receptor CL-2/CL-11; p70 killer cell inhibitory receptor; p70 natural killer cell receptor clones CL-2/CL-11; killer cell immunoglobulin-like receptor, three domains, long cytoplasmic tail, 1; CD158 antigen-like family member E; HLA-BW4-specific inhibitory NK cell receptor; MHC class I NK cell receptor; Natural killer-associated transcript 3; NKAT-3; p70 natural killer cell receptor clones CL-2/CL-11; p70 NK receptor CL-2/CL-11; CD_antigen: CD158e

KIR3DL1

KIR3DL1; KIR3DL1; KIR; NKB1; NKAT3; NKB1B; NKAT-3; CD158E1; KIR3DL1/S1; CD158E; NKAT3; NKB1; NKAT-3; p70 NK receptor CL-2/CL-11

KI3L1_HUMAN

E Coli

444

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSTSGT IDKLDIEFHLWCSNKKNAAV MDQEPAGNRT ANSEDSDEQD PEEVTYAQLD HCVFTQRKIT RPSQRPKTPP TDTILYTELP NAKPRSKVVS CP.

Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

The protein (1mg/ml) contains 25mM Tris-HCl (pH7.5) and 100mM NaCl. Sterile filtered colorless solution.

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Killer Cell

Description: Recombinant KIR3DL1 produced in E Coli is a single, non-glycosylated polypeptide chain containing 132 amino acids and having a molecular mass of 15 kDa.The KIR3DL1 is purified by proprietary chromatographic techniques. Introduction: Killer-cell immunoglobulin-like receptors (KIRs), are a family of cell surface glycoproteins found on Natural Killer (NK) Cells, which are important cells of the immune system. They control the killing function of these cells by interacting with MHC class I molecules, which are expressed on all cell types. This interaction allows them to identify virally infected cells or tumor cells that have a distinctive low level of Class I MHC on their surface. The majority of KIRs are inhibitory, which means that their recognition of MHC suppresses the cytotoxic activity of their NK cell. Only a limited number of KIRs have the capacity to activate cells. The KIR genes are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). KIR molecules are extremely polymorphic, meaning their gene sequences differ significantly between individuals, so that different individuals have different arrays/repertoires of KIR genes.The KIR proteins are categorized by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM). Whereas KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The three Ig-domain from of inhibitory killer cell Ig-like receptor 1(KIR3DL1, NKB1, nkat3, p70KIR) is a NK cell receptor for polymorphic HLA-B determinant. KIR3DLl recognizes the Bw4 determinant defined by sequence motifs at positions 77-83 of the HLA-B heavy chain. The cytoplasmic tail of KIR, which contains two immunoreceptor tyrosine-based inhibition motifs (ITIMs), mediates inhibitory signal transduction that prevents killer cell-mediated cytotoxicity. A His-tag fusion protein of KIR3DL1 cytoplasmic tail (361-444aa) was overexpressed as insoluble protein aggregates (inclusion bodies).

134268644

NP_037421.2

NM_013289.2

P43629

38,403 Da

Adaptive Immune System Pathway (366160); Antigen Processing And Presentation Pathway (83074); Antigen Processing And Presentation Pathway (485); Graft-versus-host Disease Pathway (83124); Graft-versus-host Disease Pathway (536); Immune System Pathway (106386); Immunoregulatory Interactions Between A Lymphoid And A Non-Lymphoid Cell Pathway (106413); Natural Killer Cell Mediated Cytotoxicity Pathway (83079); Natural Killer Cell Mediated Cytotoxicity Pathway (490); Validated Targets Of C-MYC Transcriptional Activation Pathway (169351)

Killer cell immunoglobulin-like receptors (KIRs) are transmembrane glycoproteins expressed by natural killer cells and subsets of T cells. The KIR genes are polymorphic and highly homologous and they are found in a cluster on chromosome 19q13.4 within the 1 Mb leukocyte receptor complex (LRC). The gene content of the KIR gene cluster varies among haplotypes, although several "framework" genes are found in all haplotypes (KIR3DL3, KIR3DP1, KIR3DL4, KIR3DL2). The KIR proteins are classified by the number of extracellular immunoglobulin domains (2D or 3D) and by whether they have a long (L) or short (S) cytoplasmic domain. KIR proteins with the long cytoplasmic domain transduce inhibitory signals upon ligand binding via an immune tyrosine-based inhibitory motif (ITIM), while KIR proteins with the short cytoplasmic domain lack the ITIM motif and instead associate with the TYRO protein tyrosine kinase binding protein to transduce activating signals. The ligands for several KIR proteins are subsets of HLA class I molecules; thus, KIR proteins are thought to play an important role in regulation of the immune response. [provided by RefSeq, Jul 2008]

KIR3DL1: Receptor on natural killer (NK) cells for HLA Bw4 allele. Inhibits the activity of NK cells thus preventing cell lysis. Belongs to the immunoglobulin superfamily. Protein type: Receptor, misc.; Membrane protein, integral. Chromosomal Location of Human Ortholog: 19q13.4. Cellular Component: integral to plasma membrane; plasma membrane. Molecular Function: HLA-B specific inhibitory MHC class I receptor activity. Biological Process: regulation of immune response; immune response; signal transduction. Disease: Human Immunodeficiency Virus Type 1, Susceptibility To

0.005 mg

140 USD

0.02 mg

205

1 mg

3490