Recombinant Human S100 Calcium Binding Protein P | MyBioSource MBS142979 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human S100 Calcium Binding Protein P

catalog :

MBS142979

quantity :

0.002 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142979

products type :

Recombinant Protein

products full name :

Recombinant Human S100 Calcium Binding Protein P

products short name :

S100 Calcium Binding Protein P

products name syn :

S100P Human; S100 Calcium Binding Protein P Human Recombinant; Protein S100-P; S100 calcium-binding protein P; S100P; S100E; MIG9

other names :

protein S100-P; Protein S100-P; protein S100-P; S100 calcium-binding protein P; migration-inducing gene 9 protein; protein S100-E; S100 calcium binding protein P; Migration-inducing gene 9 protein; MIG9; Protein S100-E; S100 calcium-binding protein P

products gene name :

S100P

other gene names :

S100P; S100P; MIG9; S100E; MIG9

uniprot entry name :

S100P_HUMAN

host :

E Coli

sequence length :

sequence :

MTELEAAMGM IIDVFSRYSG SEGSTQTLTK GELKVLMEKE LPGFLQSGKD KDAVDKLLKD LDANGDAQVD FSEFIVFVAA ITSACHKYFE KAGLK.

purity :

Greater than 95% as determined by SDS-PAGE.

form :

Filtered (0.4 um) and lyophilized from 0.5 mg/ml in 0.05M Phosphate buffer pH7.2, 0.1M NaCl. Filtered White lyophilized (freeze-dried) powder.

storage stability :

Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.

other info2 :

Solubility: Add 0.2 ml of deionized H2O and let the lyophilized pellet dissolve completely.

products categories :

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Calcium Binding Protein

products description :

Description: The Recombinant Human S100P has a molecular mass of 10.4 kDa containing 95 amino acid residues of the human S100P. Introduction: S100P was originally described as a placental protein of 95 amino acid residues shares about 50% sequence identity with the brain S100 proteins alpha and beta.S100 proteins are small dimeric members of the EF-hand superfamily of Ca(2+) binding proteins thought to participate in mediating intracellular Ca(2+) signals by binding to and thereby regulating target proteins in a Ca(2+)-dependent manner. S100P in addition to binding Ca2+, also binds Zn2+ and Mg2+. S100P gene is located on chromosome 4p16.S100P is dysregulated in the androgen-independent prostate cancer cell lines LNCaP-R, DU145, and PC3 and may play a role in the etiology of prostate cancer.In ductal hyperplasias, in situ and invasive ductal carcinoma, but not in the normal tissues, S100P overexpression is an early event that might play an important role in the immortalization of human breast epithelial cells in vitro and tumor progression in vivo.In NIH3T3 cells, the expression of S100P led to the presence of S100P in the culture medium, increased cellular proliferation, and enhanced survival following detachment from the culture substrate or after exposure to the chemotherapeutic agent 5-flurouracil. The proliferation and survival effects of S100P expression were duplicated in a time- and concentration-dependent manner by extracellular addition of purified S100P to wild-type NIH3T3 cells and correlated with the activation of Erks and NFB.To determine the mechanisms involved in these effects, we tested the hypothesis that S100P activated RAGE (Receptor for Activated Glycation End-Products). It was found that S100P coimmunoprecipitated with RAGE. Furthermore, the effects of S100P on cell signaling, proliferation and survival were blocked by agents that interfere with RAGE including administration of an amphoterin derived peptide known to antagonize RAGE activation, anti-RAGE antibodies and by expression of a dominant negative RAGE. These data suggest that S100P can act in an autocrine manner via RAGE to stimulate cell proliferation and survival.

ncbi gi num :

5174663

ncbi acc num :

NP_005971.1

ncbi gb acc num :

NM_005980.2

uniprot acc num :

P25815

ncbi mol weight :

10,400 Da

ncbi pathways :

Gastric Cancer Network 1 Pathway (760635)

ncbi summary :

The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21; however, this gene is located at 4p16. This protein, in addition to binding Ca2+, also binds Zn2+ and Mg2+. This protein may play a role in the etiology of prostate cancer. [provided by RefSeq, Jul 2008]

uniprot summary :

S100P: Homodimer. Interacts with S100PBP and S100Z. Up-regulated in various pancreatic ductal adenocarcinomas and pancreatic intraepithelial neoplasias. Belongs to the S-100 family. Chromosomal Location of Human Ortholog: 4p16. Cellular Component: microvillus membrane; cytoplasm; nucleus. Molecular Function: protein binding; RAGE receptor binding; magnesium ion binding; calcium ion binding; calcium-dependent protein binding. Biological Process: response to organic substance; endothelial cell migration

size1 :

0.002 mg

price1 :

140 USD

size2 :

0.01 mg

price2 :

205

size3 :

1 mg

price3 :

4140

more info or order :

MyBioSource product webpage