Recombinant Human Regenerating Islet-Derived 4 | MyBioSource MBS142978 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Regenerating Islet-Derived 4

catalog :

MBS142978

quantity :

0.002 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142978

products type :

Recombinant Protein

products full name :

Recombinant Human Regenerating Islet-Derived 4

products short name :

Regenerating Islet-Derived 4

products name syn :

REG4 Human; Regenerating Islet-Derived 4 Human Recombinant; Regenerating islet-derived protein 4; Reg IV; REG-like protein; Gastrointestinal secretory protein; REG4; GISP; RELP

other names :

regenerating islet-derived protein 4 isoform 1; Regenerating islet-derived protein 4; regenerating islet-derived protein 4; REG-4; REG-like protein; gastrointestinal secretory protein; reg IV; regenerating gene type IV; regenerating islet-derived protein IV; regenerating islet-derived family, member 4; Gastrointestinal secretory protein; REG-like protein; Regenerating islet-derived protein IV; Reg IV

products gene name :

REG4

other gene names :

REG4; REG4; GISP; RELP; REG-IV; GISP; RELP; REG-4; Reg IV

uniprot entry name :

REG4_HUMAN

host :

E Coli

sequence length :

158

purity :

Greater than 95% as determined by SDS-PAGE.

form :

Filtered (0.4 um) and lyophilized from 0.5 mg/ml in 20mM Tris, pH 8.0. Filtered White lyophilized (freeze-dried) powder.

storage stability :

Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.

other info2 :

Solubility: Add deionized water to a working concentration approximately 0.5 mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by appropriate sterile filter before using it in the cell culture.

products categories :

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Regenerating Islet-Derived

products description :

Description: The Recombinant Human REG-4 is manufactured with N-terminal fusion of His Tag. The Recombinant Human REG-IV His-Tagged Fusion Protein is 17.4 kDa protein containing 136 amino acid residues of the Human REG 4 and 12 additional amino acid residues His Tag (underlined). Introduction: REG protein was shown to be stimulated during the regeneration of pancreatic islets. Since then, many Reg-related proteins have been identified in humans and other animals. In human, the four REG family genes, i.e., REG 1 alpha, REG 1 beta, REG-related sequence (RS) and HIP/PAP, have so far been isolated. These Reg-related proteins are classified into four subfamilies according to their amino-acid sequences, but they share a similar structure and physiological function. Reg protein is a growth factor for pancreatic beta cells and also suggests that the administration of Reg protein could be used as another therapeutic approach for diabetes mellitus. Human REG cDNA which encodes a 166-amino acid protein with a 22-amino acid signal peptide. The amino acid sequence of human REG protein has 68% homology to that of rat Reg protein.Reg I was found to be expressed mainly in pancreatic beta and acinoductular cells as well as gastric fundic enterochromaffin-like (ECL) cells. Reg I production in ECL cells is stimulated by gastrin, as well as by the proinflammatory cytokine, cytokine-induced neutrophil chemoattractant (CINC)-2Beta. In patients with chronic hypergastrinemia, Reg production is stimulated, with the increased proliferation of gastric mucosal cells. Patients with Helicobacter pylori infection also showed increased Reg production in the gastric mucosa, partly via increased plasma gastrin concentration and partly via increased proinflammatory cytokine production. The serum concentration of the reg-protein was significantly higher in patients with various pancreatic diseases than in normal controls, and was also significantly higher in patients with acute pancreatitis or chronic relapsing pancreatitis than in patients with chronic pancreatitis. Furthermore, the serum PSP/reg-protein concentration was also significantly increased in liver cirrhosis, choledocholithiasis, and various cancers of the digestive system.

ncbi gi num :

226823233

ncbi acc num :

NP_001152824.1

ncbi gb acc num :

NM_001159352.1

uniprot acc num :

Q9BYZ8

ncbi mol weight :

14,993 Da

uniprot summary :

REG4: Calcium-independent lectin displaying mannose-binding specificity and able to maintain carbohydrate recognition activity in an acidic environment. May be involved in inflammatory and metaplastic responses of the gastrointestinal epithelium. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted, signal peptide; Secreted. Chromosomal Location of Human Ortholog: 1p13.1-p12. Cellular Component: cytoplasm; extracellular region. Molecular Function: heparin binding; calcium ion binding

size1 :

0.002 mg

price1 :

140 USD

size2 :

0.01 mg

price2 :

205

size3 :

1 mg

price3 :

4140

more info or order :

MyBioSource product webpage