product summary
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company name :
MyBioSource
product type :
protein
product name :
Recombinant Human Osteocrin
catalog :
MBS142974
quantity :
0.002 mg
price :
140 USD
more info or order :
MyBioSource product webpage
product information
catalog number :
MBS142974
products type :
Recombinant Protein
products full name :
Recombinant Human Osteocrin
products short name :
Osteocrin
products name syn :
Osteocrin Human; Osteocrin Human Recombinant; Osteocrin; Musclin; OSTN; Osteocrin
other names :
osteocrin; Osteocrin; osteocrin; osteocrin; Musclin
other gene names :
OSTN; OSTN; MUSCLIN
uniprot entry name :
OSTN_HUMAN
host :
E Coli
sequence length :
133
purity :
Greater than 95% as determined by SDS-PAGE.
form :
Filtered (0.4 um) and lyophilized from 0.5 mg/ml in 0.05M Acetate buffer, pH 4.0. Filtered White lyophilized (freeze-dried) powder.
storage stability :
Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.
other info2 :
Solubility: It is recommended to add 0.1M Acetate buffer pH4 to prepare a working stock solution of approximately 0.5 mg/mL and let the lyophilized pellet dissolve completely. For conversion into higher pH value, we recommend intensive dilution by relevant buffer to a concentration of 10ug/ml. In higher concentrations the solubility of this antigen is limited. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
products categories :
RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins
products description :
Description: The recombinant Human Osteocrin is produced with N-terminal fusion of His Tag. The Human Osteocrin His-Tagged Fusion Protein is 13.6 kDa containing 106 amino acid residues of the human Osteocrin and 16 additional amino acid residues His Tag (underlined). Introduction: Osteocrin is a recently identified secreted protein expression of which was only detected in bone, peaking just after birth and decreasing markedly with age. A 1280-bp mRNA encodes osteocrin producing a mature protein of 103 amino acids with a molecular mass of 11.4 kDa. In primary osteoblastic cell cultures osteocrin expression coincided with matrix formation then decreased in very mature cultures. Treatment of cultures with 1,25-dihydroxyvitamin D3 resulted in a rapid dose- dependent down-regulation of osteocrin expression, suggesting direct regulation. Chronic treatment of primary cultures with osteocrin-conditioned media inhibited mineralization and reduced osteocalcin and alkaline phosphatase expression. These results suggest that osteocrin represents a novel, unique vitamin D-regulated bone-specific protein that appears to act as a soluble osteoblast regulator.
ncbi gi num :
38044108
ncbi acc num :
NP_937827.1
ncbi gb acc num :
NM_198184.1
uniprot acc num :
P61366
ncbi mol weight :
14,722 Da
uniprot summary :
OSTN: Appears to modulate osteoblastic differentiation. Could also function as an autocrine and paracrine factor linked to glucose metabolism in skeletal muscle. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 3q28. Cellular Component: extracellular space. Molecular Function: hormone activity. Biological Process: negative regulation of glucose import; ossification; cell surface receptor linked signal transduction; positive regulation of cGMP biosynthetic process; negative regulation of osteoblast differentiation; cell differentiation
size1 :
0.002 mg
price1 :
140 USD
size2 :
0.01 mg
price2 :
205
size3 :
1 mg
price3 :
4140
more info or order :
MyBioSource product webpage
company information
MyBioSource
P.O. Box 153308
San Diego, CA 92195-3308
sales@mybiosource.com
https://www.mybiosource.com
1-888-627-0165
headquarters: USA
MyBioSource, LLC was orginally founded in Vancouver by three enthusiastic scientists who are passionate about providing the world with the best reagents available. Together, they form a company with a big vision known as MyBioSource. MyBioSource is now located in San Diego, California, USA.

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