catalog number :
MBS142973
products type :
Native Protein
products full name :
Human Alpha-2-HS-Glycoprotein
products short name :
Alpha-2-HS-Glycoprotein
products name syn :
AHSG; Alpha-2-HS-Glycoprotein Human; Alpha-2-HS-glycoprotein; Fetuin-A; Alpha-2-Z-globulin; Ba-alpha-2-glycoprotein; AHSG; FETUA; AHS; A2HS; HSGA; PRO2743
other names :
alpha-2-HS-glycoprotein preproprotein; Alpha-2-HS-glycoprotein; alpha-2-HS-glycoprotein; alpha-2-Z-globulin; ba-alpha-2-glycoprotein; fetuin-A; alpha-2-HS-glycoprotein; Alpha-2-Z-globulin; Ba-alpha-2-glycoprotein; Fetuin-ACleaved into the following 2 chains:Alpha-2-HS-glycoprotein chain A; Alpha-2-HS-glycoprotein chain B
products gene name :
AHSG
other gene names :
AHSG; AHSG; AHS; A2HS; HSGA; FETUA; FETUA
uniprot entry name :
FETUA_HUMAN
host :
Purified from the human plasma
purity :
Greater than 95% as determined by SDS-PAGE.
form :
Filtered (0.4 um) and lyophilized from 0.5 mg/ml in PBS pH 7.4. Filtered White lyophilized (freeze-dried) powder.
storage stability :
Store the lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.
other info2 :
Solubility: It is recommended to add deionized water to prepare a working stock solution of approximately 0.5mg/ml and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.
products categories :
RECOMBINANT & NATURAL PROTEINS; Natural Proteins
products description :
Description: The human Alpha-2-HS-Glycoprotein was purified from the human plasma. Introduction: Fetuin is a liver-produced negative acute phase protein composed of two subunits, the A and B chains.Fetuin homologs have been identified in several species including rat, sheep, pig, rabbit, guinea pig, cattle, mouse and human. Multiple physiological roles for these homologs have been suggested, including ability to bind to hydroxyapatite crystals and to specifically inhibit the tyrosine kinase (TK) activity of the insulin receptor (IR).Fetuin-A (alpha2-Heremans-Schmid glycoprotein; AHSG) is an important circulating inhibitor of calcification in vivo, and is downregulated during the acute-phase response.Sera from patients on long-term dialysis with low AHSG concentrations showed impaired ex-vivo capacity to inhibit CaxPO4 precipitation.Fetuin may influence the resolution of inflammation by modulating the phagocytosis of apoptotic cells by macrophages.ASHG blocks TGF-beta-dependent signaling in osteoblastic cells, and mice lacking ASHG display growth plate defects, increased bone formation with age, and enhanced cytokine-dependent osteogenesis.
ncbi acc num :
NP_001613.2
ncbi gb acc num :
NM_001622.2
ncbi mol weight :
39,325 Da
ncbi pathways :
BMP Receptor Signaling Pathway (137948)