Recombinant Human Adipose Differentiation-Related Protein | MyBioSource MBS142960 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Adipose Differentiation-Related Protein

catalog :

MBS142960

quantity :

0.002 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142960

products type :

Recombinant Protein

products full name :

Recombinant Human Adipose Differentiation-Related Protein

products short name :

Adipose Differentiation-Related

products name syn :

ADFP Human; Adipose Differentiation-Related Protein Human Recombinant; Adipophilin; Adipose differentiation-related protein; ADRP; ADFP; MGC10598

other names :

perilipin-2; Perilipin-2; perilipin-2; adipophilin; adipose differentiation-related protein; perilipin 2; Adipophilin; Adipose differentiation-related protein; ADRP

products gene name :

ADFP

other gene names :

PLIN2; PLIN2; ADFP; ADRP; ADFP; ADRP

uniprot entry name :

PLIN2_HUMAN

host :

E Coli

sequence length :

437

purity :

Greater than 95% as determined by SDS PAGE.

form :

Human ADFP was lyophilized from 0.5mg/ml solution containing 20mM Tris pH-7.5, and 20mM NaCl.

storage stability :

Store lyophilized protein at -20 degree C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles. Reconstituted protein can be stored at 4 degree C for a limited period of time; it does not show any change after two weeks at 4 degree C.

other info2 :

Solubility: Add deionized water to prepare a working stock solution of approximately 0.5mg/mL and let the lyophilized pellet dissolve completely. Product is not sterile! Please filter the product by an appropriate sterile filter before using it in the cell culture.

products categories :

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins

products description :

Description: ADFP Human Recombinant produced in E Coli is a signle, non-glycosylated, Polypeptide chain containing 444 amino acids and having a molecular mass of 49 kDa. The protein contains an extra 8 amino acid His tag at N-terminus. The ADFP amino acid sequence is identical to UniProtKB/Swiss-Prot entry Q99541 amino acids 4437.The ADFP is purified by proprietary chromatographic techniques. Introduction: ADFP is related with the globule surface membrane material. ADFP is a major constituent of the globule surface. Rise in mRNA levels is one of the initial indications of adipocyte differentiation. Mycobacterium leprae regulates ADFP expression to facilitate the accumulation of lipids within infected macrophages for intracellular survival. ADFP is expressed in lipid droplets of vitamin A-storing hepatic stellate cells and additionally in lipid droplets of steatotic hepatocytes. ADFP expression has a role in clear cell renal carcinoma differentiation. ADFP is a component of the lipid droplets in THP-1 cells.

ncbi gi num :

34577059

ncbi acc num :

NP_001113.2

ncbi gb acc num :

NM_001122.3

uniprot acc num :

Q99541

ncbi mol weight :

48,075 Da

ncbi pathways :

Adipogenesis Pathway (198832); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (160977); HIF-1-alpha Transcription Factor Network Pathway (138045); Metabolism Pathway (477135); Metabolism Of Lipids And Lipoproteins Pathway (160976); PPARA Activates Gene Expression Pathway (530749); Regulation Of Lipid Metabolism By Peroxisome Proliferator-activated Receptor Alpha (PPARalpha) Pathway (119544)

ncbi summary :

The protein encoded by this gene belongs to the perilipin family, members of which coat intracellular lipid storage droplets. This protein is associated with the lipid globule surface membrane material, and maybe involved in development and maintenance of adipose tissue. However, it is not restricted to adipocytes as previously thought, but is found in a wide range of cultured cell lines, including fibroblasts, endothelial and epithelial cells, and tissues, such as lactating mammary gland, adrenal cortex, Sertoli and Leydig cells, and hepatocytes in alcoholic liver cirrhosis, suggesting that it may serve as a marker of lipid accumulation in diverse cell types and diseases. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2011]

uniprot summary :

perilipin 2: May be involved in development and maintenance of adipose tissue. Belongs to the perilipin family. Protein type: Endoplasmic reticulum. Chromosomal Location of Human Ortholog: 9p22.1. Cellular Component: endoplasmic reticulum; extracellular region; plasma membrane; lipid particle; nucleus; cytosol. Biological Process: long-chain fatty acid transport; response to drug; sequestering of lipid; cellular lipid metabolic process; response to organic cyclic substance

size1 :

0.002 mg

price1 :

140 USD

size2 :

0.01 mg

price2 :

205

size3 :

1 mg

price3 :

5730

more info or order :

MyBioSource product webpage