protein

Recombinant Human Beta-Synuclein

MBS142949

0.01 mg

140 USD

Recombinant Protein

Recombinant Human Beta-Synuclein

Beta-Synuclein

SNCB Human; Beta-Synuclein Human Recombinant; Beta-synuclein; SNCB; b-Synuclein

beta-synuclein; Beta-synuclein; beta-synuclein; synuclein, beta

SNCB

SNCB; SNCB

SYUB_HUMAN

E Coli

134

MDVFMKGLSM AKEGVVAAAE KTKQGVTEAA EKTKEGVLYV GSKTREGVVQ GVASVAEKTK EQASHLGGAV FSGAGNIAAA TGLVKREEFP TDLKPEEVAQ EAAEEPLIEP LMEPEGESYE DPPQEEYQEY EPEA.

Greater than 95.0% as determined by SDS-PAGE.

The protein (1mg/ml) contains 20mM Tris-HCl buffer (pH 7.5), 0.1M NaCl and 1mM MgCl2. Sterile filtered colorless solution.

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Synuclein

Description: Recombinant Human b-Synuclein produced in E Coli is a single, non-glycosylated polypeptide chain (1-134 a.a) having a molecular mass of 14.2kDa (molecular size on SDS-PAGE will appear higher). SNCB is extremely heatresistant and has a chaperone-like activity. Introduction: b-synuclein (amino acids 1-134), an acidic neuronal protein of 134 amino acids, is extremely heat-resistant. b-synucelin also has a chaperone-like activity. Recently, b-synuclein has been suggested to inhibit a-synuclein aggregation. b and a-synuclein are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease.

48255903

NP_001001502.1

NM_001001502.1

Q16143

14,288 Da

The protein encoded by this gene is highly homologous to alpha-synuclein. These proteins are abundantly expressed in the brain and putatively inhibit phospholipase D2 selectively. The encoded protein, which may play a role in neuronal plasticity, is abundant in neurofibrillary lesions of patients with Alzheimer disease. This protein has been shown to be highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease; however, no direct relation to Parkinson disease has been established. Two transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Jul 2008]

SNCB: a member of the synuclein family. Abundantly expressed in the brain. Inhibits phospholipase D2 selectively. May play a role in neuronal plasticity, is abundant in neurofibrillary lesions of Alzheimer s patients. Highly expressed in the substantia nigra of the brain, a region of neuronal degeneration in patients with Parkinson disease. Protein type: Adaptor/scaffold. Chromosomal Location of Human Ortholog: 5q35. Cellular Component: nucleoplasm; Golgi apparatus; growth cone; cell soma; mitochondrion; cytoplasm; terminal button; inclusion body. Molecular Function: phospholipase inhibitor activity; beta-tubulin binding; calcium ion binding; alpha-tubulin binding. Biological Process: synaptic transmission; negative regulation of catalytic activity; synapse organization and biogenesis; negative regulation of neuron apoptosis; dopamine metabolic process. Disease: Dementia, Lewy Body

0.01 mg

140 USD

0.05 mg

205

1 mg

1910