protein

Human Alpha-1 AntiChymotrypsin

MBS142933

0.02 mg

140 USD

Native Protein

Human Alpha-1 AntiChymotrypsin

Alpha-1 AntiChymotrypsin

SERPINA3 Human; Alpha-1 AntiChymotrypsin Human; Alpha-1-antichymotrypsin; ACT; Cell growth-inhibiting gene 24/25 protein; SERPINA3; AACT; A1ACT; GIG24; GIG25; MGC88254

alpha-1-antichymotrypsin; Alpha-1-antichymotrypsin; alpha-1-antichymotrypsin; cell growth-inhibiting gene 24/25 protein; growth-inhibiting protein 24; growth-inhibiting protein 25; serine (or cysteine) proteinase inhibitor, clade A, member 3; serpin A3; serpin peptidase inhibitor, clade A (alpha-1 antiproteinase, antitrypsin), member 3; Cell growth-inhibiting gene 24/25 protein; Serpin A3Alpha-1-antichymotrypsin His-Pro-less

SERPINA3

SERPINA3; SERPINA3; ACT; AACT; GIG24; GIG25; AACT; ACT

AACT_HUMAN

Human Serum

423

Greater than 99.0%.

Lyophilized from 0.02M NH4HCO3. Sterile Filtered White lyophilized (freeze-dried) powder.

Human SERPINA3 although stable at room temperature for 3 weeks, should be stored between 2-8 degree C.

Solubility: It is recommended to reconstitute the lyophilized human A1ACT in phosphate buffer pH > 7.0 containing 0.15M NaCl. Human Virus Test: Starting material tested and found negative for HIV I & II antibodies, Hepatitis B surface antigen, and Hepatitis C antibodies.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Serpin

Description: Human Alpha-1 AntiChymotrypsin produced from normal human serum having a molecular mass of 68kDa. Introduction: Alpha 1 ACT is an early-stage acute-phase plasma protein and a serpin that preferentially inactivates chymotrypsin, cathepsin G, and chymase. Alpha-1- ACT, a serine protease inhibitor, is tightly associated with amyloid plaques in Alzheimer's disease (AD) and in normal aged human and monkey brain.Regulation of the serine proteases and serine protease inhibitors plays an important role in neuromuscular differentiation. Prostate specific antigen (PSA), a chymotrypsin-like serine protease, is predominantly complexed to Alpha-1-ACT.

50659080

NP_001076.2

NM_001085.4

P01011

10,717 Da

Selenium Pathway (198825)

The protein encoded by this gene is a plasma protease inhibitor and member of the serine protease inhibitor class. Polymorphisms in this protein appear to be tissue specific and influence protease targeting. Variations in this protein's sequence have been implicated in Alzheimer's disease, and deficiency of this protein has been associated with liver disease. Mutations have been identified in patients with Parkinson disease and chronic obstructive pulmonary disease. [provided by RefSeq, Jul 2008]

SERPINA3: Although its physiological function is unclear, it can inhibit neutrophil cathepsin G and mast cell chymase, both of which can convert angiotensin-1 to the active angiotensin-2. Belongs to the serpin family. 3 isoforms of the human protein are produced by alternative splicing. Protein type: Secreted; Secreted, signal peptide. Chromosomal Location of Human Ortholog: 14q32.1. Cellular Component: extracellular space; extracellular region; intracellular; nucleus. Molecular Function: serine-type endopeptidase inhibitor activity; protein binding; DNA binding. Biological Process: regulation of lipid metabolic process; maintenance of gastrointestinal epithelium; acute-phase response; inflammatory response

0.02 mg

140 USD

0.1 mg

205

1 mg

505