protein

Human Bivalirudin

MBS142912

1 mg

140 USD

Native Protein

Human Bivalirudin

Bivalirudin

Bivalirudin; Bivalirudin; Bivalirudin

Greater than 98.0% as determined by (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

The protein (1mg/ml) was lyophilized with 0.5mg Manntiol and sodium hydroxide 50 ug pH-5.5. Sterile Filtered White lyophilized (freeze-dried) powder.

Lyophilized Bivalirudin although stable at room temperature for 3 weeks, should be stored desiccated below -18 degree C. Upon reconstitution Bivalirudin should be stored at 4 degree C between 2-7 days and for future use below -18 degree C.For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

Solubility: It is recommended to reconstitute the lyophilized Bivalirudin in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions.

RECOMBINANT & NATURAL PROTEINS; Natural Proteins; AntiCoagulation Factors

Description: The active of Bivalirudin substance is a synthetic 20 amino acid peptide. The amino acid sequence is Phe-Pro-Arg-Pro-Gly-Gly-Gly-Gly- Asn-Gly-Asp-Phe-Glu-Glu-Ile- Pro-Glu-Glu-Tyr-Leu. The Mw is 2180 dalton. Introduction: Bivalirudin directly inhibits thrombin by specifically binding as well to the catalytic site and to the anion-binding exosite of circulating and clot-bound thrombin. Bivalirudin is a specific and reversible direct thrombin inhibitor. Thrombin, which is a serine protease, plays a central role in the thrombotic process; it cleaves fibrinogen into fibrin monomers and activates Factor XIII to Factor XIIIa, allowing fibrin to develop a covalently cross-linked structure which stabilizes the thrombus. Thrombin also activates Factors V and VIII, which promotes further thrombin generation, activates platelets, stimulating aggregation and granule release.

1 mg

140 USD

5 mg

205

100 mg

550