Human Cardiac Troponin-T | MyBioSource MBS142897 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Human Cardiac Troponin-T

catalog :

MBS142897

quantity :

0.01 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142897

products type :

Native Protein

products full name :

Human Cardiac Troponin-T

products short name :

Cardiac Troponin-T

products name syn :

TnT Human; Cardiac Troponin T Human; Troponin T cardiac muscle; TnTc; Cardiac muscle troponin T; cTnT; TNNT2; CMH2; CMPD2; MGC3889; Troponin-T

other names :

troponin T, cardiac muscle isoform 1; Troponin T, cardiac muscle; troponin T, cardiac muscle; cardiomyopathy, dilated 1D (autosomal dominant); cardiomyopathy, hypertrophic 2; troponin T2, cardiac; troponin T type 2 (cardiac); Cardiac muscle troponin T; cTnT

other gene names :

TNNT2; TNNT2; CMH2; RCM3; TnTC; cTnT; CMD1D; CMPD2; LVNC6; TnTc; cTnT

uniprot entry name :

TNNT2_HUMAN

host :

Human Cardiac Tissue

sequence length :

295

purity :

Greater than 95.0% as determined by SDS-PAGE.

form :

Human Cardiac Troponin T in 6M Urea, 250mM NaCl, 50mM Tris-HCl, 15mM b-mercaptoethanol, 1mM EDTA, pH-7.2.

concentration :

1.88mg/ml

storage stability :

Human TnT although stable at 10 degree C for 7 days, should be stored desiccated below -18 degree C. Please prevent freeze-thaw cycles.

other info1 :

Physical Appearance: Sterile Filtered colorless liquid formualtion (1.88mg/ml)

other info2 :

Human Virus Test: Blood samples from tissue donors used in the manufacture of this product tested negative for HIV-1,2, HbsAg, HCV and RPR/STS.

products categories :

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Cardiac Troponin

products description :

Description: Human Cardiac Troponin T produced from Human Cardiac Tissue, having a molecular weight of approximately 35 kDa.The Cardiac troponin-T is purified using a combination of ion-exchange and affinity chromatography steps. Introduction: Troponin-T is one of three subunits that form the troponin complex of the thin filaments of striated muscle, it regulates muscle contraction in response to alterations in intracellular calcium ion concentration. TnTc is expressed only in the heart and has proved to be a specific biomarker for heart disease. Mutations in TNNT2 are associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Alternative splicing results in many tissue-specific isoforms.

ncbi gi num :

48255877

ncbi acc num :

NP_000355.2

ncbi gb acc num :

NM_000364.3

uniprot acc num :

P45379

ncbi mol weight :

30,681 Da

ncbi pathways :

Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); Cardiac Progenitor Differentiation Pathway (712094); Cardiac Muscle Contraction Pathway (93344); Cardiac Muscle Contraction Pathway (93992); Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285); Hypertrophic Cardiomyopathy (HCM) Pathway (114229); Hypertrophic Cardiomyopathy (HCM) Pathway (106591); Muscle Contraction Pathway (106261)

ncbi summary :

The protein encoded by this gene is the tropomyosin-binding subunit of the troponin complex, which is located on the thin filament of striated muscles and regulates muscle contraction in response to alterations in intracellular calcium ion concentration. Mutations in this gene have been associated with familial hypertrophic cardiomyopathy as well as with dilated cardiomyopathy. Transcripts for this gene undergo alternative splicing that results in many tissue-specific isoforms, however, the full-length nature of some of these variants has not yet been determined. [provided by RefSeq, Jul 2008]

uniprot summary :

TNNT2: Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Heart. The fetal heart shows a greater expression in the atrium than in the ventricle, while the adult heart shows a greater expression in the ventricle than in the atrium. Isoform 6 predominates in normal adult heart. Isoforms 1, 7 and 8 are expressed in fetal heart. Isoform 7 is also expressed in failing adult heart. Belongs to the troponin T family. 11 isoforms of the human protein are produced by alternative splicing. Protein type: Motility/polarity/chemotaxis; Motor. Chromosomal Location of Human Ortholog: 1q32. Cellular Component: sarcomere; troponin complex; cytosol; striated muscle thin filament. Molecular Function: troponin C binding; structural constituent of cytoskeleton; troponin I binding; ATPase activity; tropomyosin binding; actin binding. Biological Process: positive regulation of ATPase activity; regulation of muscle contraction; metabolic process; atrial cardiac muscle morphogenesis; ventricular cardiac muscle morphogenesis; sarcomere organization; response to calcium ion; negative regulation of ATPase activity; regulation of heart contraction; muscle filament sliding. Disease: Cardiomyopathy, Familial Restrictive, 3; Cardiomyopathy, Dilated, 1d; Cardiomyopathy, Familial Hypertrophic, 2

size1 :

0.01 mg

price1 :

140 USD

size2 :

0.05 mg

price2 :

205

size3 :

1 mg

price3 :

1595

more info or order :

MyBioSource product webpage