Recombinant Human Troponin I Type 2 | MyBioSource MBS142896 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Troponin I Type 2

catalog :

MBS142896

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142896

products type :

Recombinant Protein

products full name :

Recombinant Human Troponin I Type 2

products short name :

Troponin I Type 2

products name syn :

TNNI2 Human; Troponin I Type 2 Human Recombinant; Troponin I fast skeletal muscle; Troponin I fast-twitch isoform; TNNI2; DA2B; FSSV; fsTnI; AMCD2B

other names :

troponin I, fast skeletal muscle isoform 1; Troponin I, fast skeletal muscle; troponin I, fast skeletal muscle; troponin I fast twitch 2; troponin I, fast-twitch isoform; troponin I, fast-twitch skeletal muscle isoform; troponin I, skeletal, fast; troponin I type 2 (skeletal, fast); Troponin I, fast-twitch isoform

products gene name :

TNNI2

other gene names :

TNNI2; TNNI2; DA2B; FSSV; fsTnI; AMCD2B

uniprot entry name :

TNNI2_HUMAN

host :

E Coli

sequence length :

182

purity :

Greater than 85.0% as determined by SDS-PAGE.

form :

The protein solution contains 20mM Tris-HCl, 500mM NaCl and 10mM b-ME, pH 7.5. Sterile Filtered colourless liquid formualtion.

storage stability :

TNNI2 Human although stable at 10 degree C for 7 days, should be stored below -18 degree C.Please prevent freeze-thaw cycles.

products categories :

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Cardiac Troponin

products description :

Description: Skeletal isoforms of Troponin I were suggested to be used as markers of acute and chronic skeletal muscle injuries. In skeletal muscles Troponin I is presented by two forms, slow (21.6 kDa) and fast (21.2 kDa) skeletal. The protein (Fast Skeletal Troponin I) migrates on SDS-PAGE to approximately 26.5kDa. Introduction: TNNI2 is a fast-twitch skeletal muscle protein, belongs to the troponin I gene family, and is part of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, together with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. TNNI2 is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. Other than muscle tissues, TNNI2 is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a coactivator of estrogen receptor-related receptor alpha. Furthermore, TNNI2 suppresses tumor growth in human ovarian carcinoma. Mutations in the TNNI2 gene cause myopathy and distal arthrogryposis type 2B.

ncbi gi num :

224967057

ncbi acc num :

NP_001139301.1

ncbi gb acc num :

NM_001145829.1

uniprot acc num :

P48788

ncbi mol weight :

21,355 Da

ncbi pathways :

Muscle Contraction Pathway (106261); Striated Muscle Contraction Pathway (198903); Striated Muscle Contraction Pathway (106262)

ncbi summary :

This gene encodes a fast-twitch skeletal muscle protein, a member of the troponin I gene family, and a component of the troponin complex including troponin T, troponin C and troponin I subunits. The troponin complex, along with tropomyosin, is responsible for the calcium-dependent regulation of striated muscle contraction. Mouse studies show that this component is also present in vascular smooth muscle and may play a role in regulation of smooth muscle function. In addition to muscle tissues, this protein is found in corneal epithelium, cartilage where it is an inhibitor of angiogenesis to inhibit tumor growth and metastasis, and mammary gland where it functions as a co-activator of estrogen receptor-related receptor alpha. This protein also suppresses tumor growth in human ovarian carcinoma. Mutations in this gene cause myopathy and distal arthrogryposis type 2B. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009]

uniprot summary :

TNNI2: Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. Defects in TNNI2 are a cause of distal arthrogryposis type 2B (DA2B); also known as arthrogryposis multiplex congenita, distal, type 2B (AMCD2B). DA2B is a form of inherited multiple congenital contractures. Affected individuals have vertical talus, ulnar deviation in the hands, severe camptodactyly, and a distinctive face characterized by a triangular shape, prominent nasolabial folds, small mouth and a prominent chin. Belongs to the troponin I family. Protein type: Motility/polarity/chemotaxis. Chromosomal Location of Human Ortholog: 11p15.5. Cellular Component: troponin complex; cytosol; nucleus. Molecular Function: troponin T binding; protein binding; actin binding. Biological Process: skeletal muscle contraction; regulation of muscle contraction; positive regulation of transcription, DNA-dependent; muscle filament sliding. Disease: Arthrogryposis, Distal, Type 2b

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

1 mg

price3 :

2920

more info or order :

MyBioSource product webpage