protein

Recombinant Human Guanine Nucleotide Binding Protein Beta Polypeptide 3

MBS142887

0.005 mg

140 USD

Recombinant Protein

Recombinant Human Guanine Nucleotide Binding Protein Beta Polypeptide 3

[Guanine Nucleotide Binding Protein Beta Polypeptide 3]

[GNB3 Human; Guanine Nucleotide Binding Protein Beta Polypeptide 3 Human Recombinant; Transducin Beta Chain 3; G Protein; Beta-3 Subunit; GTP-Binding Regulatory Protein Beta-3 Chain; Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Beta Subunit 3; Guanine Nucleotide-Binding Protein G(I)/G(S)/G(T) Subunit Beta-3; Hypertension Associated Protein; Guanine Nucleotide Binding Protein (G Protein); Beta Polypeptide 3; GNB3]

[guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3 isoform 2; Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-3; G protein, beta-3 subunit; GTP-binding regulatory protein beta-3 chain; guanine nucleotide-binding protein G(I)/G(S)/G(T) beta subunit 3; hypertension associated protein; transducin beta chain 3; guanine nucleotide binding protein (G protein), beta polypeptide 3; Transducin beta chain 3]

[GNB3]

[GNB3; GNB3]

GBB3_HUMAN

E Coli

339

MGSSHHHHHH SSGLVPRGSH MGS MGEMEQL RQEAEQLKKQ IADARKACAD VTLAELVSGL EVVGRVQMRT RRTLRGHLAK IYAMHWATDS KLLVSASQDG KLIVWDSYTT NKVHAIPLRS SWVMTCAYAP SGNFVACGGL DNMCSIYNLK SREGNVKVSR ELSAHTGYLS CCRFLDDNNI VTSSGDTTCA LWDIETGQQK TVFVGHTGDC MSLAVSPDFN LFISGACDAS AKLWDVREGT CRQTFTGHES DINAICFFPN GEAICTGSDD ASCRLFDLRA DQELICFSHE SIICGITSVA FSLSGRLLFA GYDDFNCNVW DSMKSERVGI LSGHDNRVSC LGVTADGMAV ATGSWDSFLK IWN

Greater than 80.0% as determined by SDS-PAGE.

GNB3 protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH8.0), 10% glycerol and 0.4M Urea. Sterile Filtered clear solution.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Guanine Nucleotide Binding Protein

Description: GNB3 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 363 amino acids (1-340 a.a) and having a molecular mass of 39.6kDa.GNB3 is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Introduction: GNB3 belongs to the WD repeat G protein beta family. GNB3 is an important regulator of alpha subunit, as well as of certain signal transduction receptor and effector. A single-nucleotide polymorphism (C825T) in GNB3 is linked with essential hypertension and obesity. In addition, this polymorphism is also linked with the occurrence of the splice variant GNB3-s, which seems to have increased activity. GNB3-s is an example of alternative splicing caused by a nucleotide change outside of the splice donor and acceptor sites. Further splice variants may exist for GNB3, however they have not been fully described. Among the diseases associated with GNB3 are syncope, and aortic coarctation.

662033915

NP_001284500.1

NM_001297571.1

P16520

32,633 Da

ADP Signalling Through P2Y Purinoceptor 1 Pathway (161061); ADP Signalling Through P2Y Purinoceptor 12 Pathway (161060); Activation Of G Protein Gated Potassium Channels Pathway (366226); Activation Of GABAB Receptors Pathway (187181); Activation Of Kainate Receptors Upon Glutamate Binding Pathway (161043); Adrenaline,noradrenaline Inhibits Insulin Secretion Pathway (105923); Alcoholism Pathway (585563); Alcoholism Pathway (587116); Aquaporin-mediated Transport Pathway (187187); Ca2+ Pathway (1127532)

0.005 mg

140 USD

0.02 mg

205

1 mg

3515