catalog number :
MBS142884
products type :
Recombinant Protein
products full name :
Recombinant Human RO-60 (SS-A) RO-60 Human
products short name :
TROVE Domain Family
products name syn :
TROVE2 Human; TROVE Domain Family Member 2 Human Recombinant; 60 kDa SS-A/Ro ribonucleoprotein; 60 kDa ribonucleoprotein Ro; RoRNP; 60 kDa Ro protein; Ro 60 kDa autoantigen; TROVE domain family member 2; Sjoegren syndrome type A antigen; SS-A; Sjoegren syndrome antigen A2; TROVE2; RO60; SSA2; RO-60
other names :
60 kDa SS-A/Ro ribonucleoprotein isoform 1; 60 kDa SS-A/Ro ribonucleoprotein; 60 kDa SS-A/Ro ribonucleoprotein; 60 kDa ribonucleoprotein Ro; Sjogren syndrome antigen A2 (60kD, ribonucleoprotein autoantigen SS-A/Ro); gastric cancer multi-drug resistance protein; sjoegren syndrome type A antigen; TROVE domain family, member 2; Ro 60 kDa autoantigen; Sjoegren syndrome antigen A2; Sjoegren syndrome type A antigen; SS-A; TROVE domain family member 2
products gene name :
TROVE2
other gene names :
TROVE2; TROVE2; RO60; SSA2; RORNP; RO60; SSA2; 60 kDa Ro protein; 60 kDa ribonucleoprotein Ro; RoRNP; SS-A
uniprot entry name :
RO60_HUMAN
purity :
Greater than 90.0% as determined by SDS-PAGE.
form :
The protein solution (0.671mg/ml) contains 6M Urea, 500mM NaCl, 500mM imidazole and 10mM Tris pH-6. Sterile Filtered clear solution.
storage stability :
RO-60 although stable at 4 degree C for 3 weeks, should be stored below -18 degree C. Please prevent freeze-thaw cycles.
other info2 :
Protein Content: Protein quantitation was carried out by using 0.5 - 2.0 mg/ml Bradford assay vs. BSA.
products categories :
RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; TROVE Domain Family
products description :
Description: RO-60 Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain having a molecular mass of 60kDa.The RO-60 is purified by proprietary chromatographic techniques. Introduction: Ro 60 kDa autoantigen is an RNA-binding protein that binds to several small cytoplasmic RNA molecules known as Y RNAs. SSA2 may stabilize these RNAs from degradation. Sera taken from patients with Systemic Lupus Erythematosus (SLE) often contains antibodies that react with the normal cellular SSA2 protein as if this antigen was foreign.
ncbi acc num :
NP_001035828.1
ncbi gb acc num :
NM_001042369.2
ncbi mol weight :
59,270 Da
ncbi pathways :
Systemic Lupus Erythematosus Pathway (83122); Systemic Lupus Erythematosus Pathway (534)
uniprot summary :
SSA2: RNA-binding protein that binds to several small cytoplasmic RNA molecules known as Y RNAs. May stabilize these RNAs from degradation. Belongs to the Ro 60 kDa family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: RNA-binding. Chromosomal Location of Human Ortholog: 1q31. Cellular Component: nucleoplasm; cytoplasm; ribonucleoprotein complex. Molecular Function: RNA binding; metal ion binding; U2 snRNA binding. Biological Process: transcription from RNA polymerase III promoter; immune system development; smoothened signaling pathway; response to UV. Disease: Heart Block, Congenital