Recombinant Human LA / SS-B | MyBioSource MBS142882 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human LA / SS-B

catalog :

MBS142882

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142882

products type :

Recombinant Protein

products full name :

Recombinant Human LA / SS-B

products short name :

LA / SS-B

products name syn :

LA/SS-B Human; LA / SS-B Human Recombinant; Lupus La protein; Sjoegren syndrome type B antigen; SS-B; La ribonucleoprotein; La autoantigen; SSB; La; LARP3; LA/SS-B; La(SS-B)

other names :

lupus La protein; Lupus La protein; lupus La protein; La ribonucleoprotein domain family, member 3; SS-B; SS-B/La protein; autoantigen La; la autoantigen; lupus La antigen; sjoegren syndrome type B antigen; Sjogren syndrome antigen B (autoantigen La); La autoantigen; La ribonucleoprotein; Sjoegren syndrome type B antigen; SS-B

products gene name :

LA/SS-B

other gene names :

SSB; SSB; La; LARP3; La/SSB; SS-B

uniprot entry name :

LA_HUMAN

host :

Sf9 Insect Cells

sequence length :

408

purity :

Greater than 95.0% as determined by SDS-PAGE.

form :

The protein solution (0.81mg/ml) contains 20mM HEPES, pH 7.5, 400mM NaCl, 20% Glycerol. Sterile Filtered clear solution.

concentration :

0.81 mg/ml

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. Avoid multiple freeze-thaw cycles.

other info1 :

Volume: 24.6ul

products categories :

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins

products description :

Description: LA/SS-B Human Recombinant produced in SF9 is a single, glycosylated, polypeptide chain having a calculated molecular mass of 52 kDa, is fused to a hexahistidine purification tag.The LA/SS-B is purified by proprietary chromatographic techniques. Introduction: The La protein is a 47 kDa polypeptide that frequently acts as an autoantigen in systemic lupus erythematosus and Sjogren's syndrome patients. La is involved in various aspects of RNA metabolism, including binding and protecting 3-prime UUU(OH) elements of newly RNA polymerase III - transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs linked to hepatitis C virus. It occurs in both the nucleus and the cytoplasm, where it assumes different roles. In the nucleus, La protein facilitates the production of tRNAs, acting as an RNA polymerase III (RNAP III) transcription factor by attaching to the U-rich 3'UTR of nascent transcripts, aiding in their folding and maturation. In the cytoplasm, La protein facilitates the translation of specific mRNAs, acting as a translation factor. As an RNA binding protein (RBP), La protein associates with subsets of mRNAs which contain a 5'-terminal oligopyrimidine (5'TOP) motif known to direct protein synthesis. The binding of La protein to particular classes of RNA molecules regulates their downstream processing, guards them from endonuclease digestion, and organizes their export from the nucleus. La/SS-B appears to be readily disposed to proteolysis, which results in many smaller (42kD, 320, and 270) nevertheless still immunoreactive polypeptides. La/SS-B antigen is strongly conserved across species. Anti-La/SS-B autoantibodies were originally found as precipitating autoantibodies in sera of Sjogren's Syndrome patients and referred to as SjT. Anti-La/SS-B precipitins are most frequently found in Sjogren's Syndrome, Systemic Lupus Erythematosus (SLE) and Subacute Cutaneous Lupus. Also, there seems to be a correlation between anti-La/SS-B and the absence of nephritis in SLE patients.

ncbi gi num :

659667952

ncbi acc num :

NP_001281074.1

ncbi gb acc num :

NM_001294145.1

uniprot acc num :

P05455

ncbi mol weight :

46,837 Da

ncbi pathways :

Gene Expression Pathway (105937); RNA Polymerase I, RNA Polymerase III, And Mitochondrial Transcription Pathway (160948); RNA Polymerase III Abortive And Retractive Initiation Pathway (160949); RNA Polymerase III Transcription Pathway (106561); RNA Polymerase III Transcription Termination Pathway (106567); Systemic Lupus Erythematosus Pathway (83122); Systemic Lupus Erythematosus Pathway (534)

ncbi summary :

The protein encoded by this gene is involved in diverse aspects of RNA metabolism, including binding and protecting poly(U) termini of nascent RNA polymerase III transcripts from exonuclease digestion, processing 5' and 3' ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. Autoantibodies reacting with this protein are found in the sera of patients with Sjogren syndrome and systemic lupus erythematosus. Alternative promoter usage results in two different transcript variants which encode the same protein. [provided by RefSeq, Jun 2014]

uniprot summary :

SSB: a nuclear protein that plays a role in the transcription of RNA polymerase III. It is most probably a transcription termination factor. Binds to the 3 termini of virtually all nascent polymerase III transcripts. It is associated with precursor forms of RNA polymerase III transcripts including tRNA and 4.5S, 5s, 7s, and 7-2 RNAs. Protein type: Transcription initiation complex. Chromosomal Location of Human Ortholog: 2q31.1. Cellular Component: nucleus; ribonucleoprotein complex. Molecular Function: mRNA binding; protein binding; nucleotide binding; tRNA binding. Biological Process: RNA processing; histone mRNA metabolic process; tRNA modification

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

1 mg

price3 :

3395

more info or order :

MyBioSource product webpage