Recombinant Human Cardiac Troponin-C | MyBioSource MBS142877 product information

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product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Cardiac Troponin-C

catalog :

MBS142877

quantity :

0.02 mg

price :

140 USD

product information

catalog number :

MBS142877

products type :

Recombinant Protein

products full name :

Recombinant Human Cardiac Troponin-C

products short name :

Cardiac Troponin-C

products name syn :

TNC Human; Cardiac Trponin C Human Recombinant; Troponin C slow skeletal and cardiac muscles; TN-C; TNNC1; TNNC; TNC; CMD1Z; Troponin-C

other names :

troponin C, slow skeletal and cardiac muscles; Troponin C, slow skeletal and cardiac muscles; troponin C, slow skeletal and cardiac muscles; cardiac troponin C; slow twitch skeletal/cardiac muscle troponin C; troponin C1, slow; troponin C type 1 (slow)

other gene names :

TNNC1; TNNC1; TNC; TN-C; TNNC; CMD1Z; CMH13; TNNC; TN-C

uniprot entry name :

TNNC1_HUMAN

host :

E Coli

sequence length :

161

purity :

Greater than 95.0% as determined by both:(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

form :

The protein solution contains 150mM NaCl, 10mM sodium phosphate, 0.05% NaN3, pH 7.0. Sterile Filtered clear solution.

other info2 :

Protein Content: Protein quantitation was carried out by using 0.25 - 5.0 mg/ml Bradford assay vs. BSA.

products categories :

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Cardiac Troponin

products description :

Description: Recombinant Human TNC produced in E Coli is a single, non-glycosylated, polypeptide chain having a molecular mass of 18,020 Dalton.The TNC is purified by proprietary chromatographic techniques. Introduction: Troponin is a fundamental regulatory protein of striated muscle contraction, and together with tropomyosin, is positioned on the actin filament. Troponin has 3 subunits: TnI- the inhibitor of actomyosin ATPase; TnT- contains the binding site for tropomyosin; and TnC- the protein encoded by the TNNC1 gene. The binding of calcium to TnC stops the inhibitory action of TnI, consequently allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in the TNNC1 gene are linked to cardiomyopathy dilated type 1Z.

ncbi gi num :

4507615

ncbi acc num :

NP_003271.1

ncbi gb acc num :

NM_003280.2

uniprot acc num :

P63316

ncbi mol weight :

18,403 Da

ncbi pathways :

Adrenergic Signaling In Cardiomyocytes Pathway (908257); Adrenergic Signaling In Cardiomyocytes Pathway (909696); Calcium Signaling Pathway (83050); Calcium Signaling Pathway (459); Cardiac Muscle Contraction Pathway (93344); Cardiac Muscle Contraction Pathway (93992); Dilated Cardiomyopathy Pathway (121494); Dilated Cardiomyopathy Pathway (121285); Hypertrophic Cardiomyopathy (HCM) Pathway (114229); Hypertrophic Cardiomyopathy (HCM) Pathway (106591)

ncbi summary :

Troponin is a central regulatory protein of striated muscle contraction, and together with tropomyosin, is located on the actin filament. Troponin consists of 3 subunits: TnI, which is the inhibitor of actomyosin ATPase; TnT, which contains the binding site for tropomyosin; and TnC, the protein encoded by this gene. The binding of calcium to TnC abolishes the inhibitory action of TnI, thus allowing the interaction of actin with myosin, the hydrolysis of ATP, and the generation of tension. Mutations in this gene are associated with cardiomyopathy dilated type 1Z. [provided by RefSeq, Oct 2008]

uniprot summary :

TNNC1: Troponin is the central regulatory protein of striated muscle contraction. Tn consists of three components: Tn-I which is the inhibitor of actomyosin ATPase, Tn-T which contains the binding site for tropomyosin and Tn-C. The binding of calcium to Tn-C abolishes the inhibitory action of Tn on actin filaments. Defects in TNNC1 are the cause of cardiomyopathy dilated type 1Z (CMD1Z). Dilated cardiomyopathy is a disorder characterized by ventricular dilation and impaired systolic function, resulting in congestive heart failure and arrhythmia. Patients are at risk of premature death. Defects in TNNC1 are the cause of familial hypertrophic cardiomyopathy type 13 (CMH13). A hereditary heart disorder characterized by ventricular hypertrophy, which is usually asymmetric and often involves the interventricular septum. The symptoms include dyspnea, syncope, collapse, palpitations, and chest pain. They can be readily provoked by exercise. The disorder has inter- and intrafamilial variability ranging from benign to malignant forms with high risk of cardiac failure and sudden cardiac death. Belongs to the troponin C family. Protein type: Motility/polarity/chemotaxis; Calcium-binding. Chromosomal Location of Human Ortholog: 3p21.1. Cellular Component: nucleoplasm; troponin complex; mitochondrion; cytosol; actin cytoskeleton. Molecular Function: troponin T binding; actin filament binding; protein binding; protein homodimerization activity; troponin I binding; calcium ion binding; calcium-dependent protein binding. Biological Process: response to metal ion; regulation of ATPase activity; regulation of muscle contraction; diaphragm contraction; ventricular cardiac muscle morphogenesis; regulation of muscle filament sliding speed; cardiac muscle contraction; muscle filament sliding. Disease: Cardiomyopathy, Dilated, 1z; Cardiomyopathy, Familial Hypertrophic, 13

size1 :

0.02 mg

price1 :

140 USD

size2 :

0.1 mg

price2 :

205

size3 :

1 mg

price3 :

940