Human Coagulation Factor VIII | MyBioSource MBS142873 product information

product summary

request information :

company name :

MyBioSource

product type :

protein

product name :

Human Coagulation Factor VIII

catalog :

MBS142873

quantity :

200 IU

price :

545 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142873

products type :

Native Protein

products full name :

Human Coagulation Factor VIII

products short name :

Coagulation Factor VIII

products name syn :

F8 Human; Coagulation Factor VIII Human; Coagulation factor VIII; Procoagulant component; Antihemophilic factor; AHF; F8; F8C; F8B; HEMA; FVIII; DXS1253E; F8 protein

other names :

coagulation factor VIII isoform a; Coagulation factor VIII; coagulation factor VIII; antihemophilic factor; coagulation factor VIIIc; factor VIII F8B; coagulation factor VIII, procoagulant component; Antihemophilic factor; AHF; Procoagulant componentCleaved into the following 4 chains:Factor VIIIa heavy chain, 200 kDa isoform; Factor VIIIa heavy chain, 92 kDa isoform; Factor VIII B chain; Factor VIIIa light chain

products gene name :

other gene names :

F8; F8; AHF; F8B; F8C; HEMA; FVIII; DXS1253E; F8C; AHF

uniprot entry name :

FA8_HUMAN

host :

Human Plasma

sequence length :

2351

form :

The lyophilized protein 200IU/ml was lyophilized from a sterile solution containing 1.5% Glycine, 160mM Calcium chloride and 25mM NaCitrate and 25mM NaCl. Sterile Filtered White lyophilized (freeze-dried) powder.

storage stability :

Lyophilized Factor-VIII although stable at room temperature for 1 week, should be stored desiccated between 2-8 degree C. Upon reconstitution Factor-VIII should be storedat 4 degree C.

other info2 :

Solubility: It is recommended to reconstitute the lyophilized Factor-VIII in sterile 18M Omega -cm H2O at a concentration of 200IU/ml, which can then be further diluted to other aqueous solutions. Make sure that the vial has reached room temperature prior to its reconstitution, otherwise it might precipitate. Human Virus Test: The plasma is collected from donors with Hepatitis B vaccinated. Each unit of plasma has been tested for HBsAg, Anti-HIV-1/2 plus O and Anti-HCV by using the imported kits which are approved by Federal Drug Administration (FDA). Biological Activity: The potency per mg was tested and found to be 150 Units/mg.

products categories :

RECOMBINANT & NATURAL PROTEINS; Natural Proteins; Coagulation Factors

products description :

Description: Human Facor VIII produced from Human Plasma is effective in the correction and prevention of severe bleeding episodes attributed to Factor VIII deficiency.The Factor-VIII is purified by proprietary chromatographic techniques. Introduction: Coagulation factor VIII participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder.

ncbi gi num :

4503647

ncbi acc num :

NP_000123.1

ncbi gb acc num :

NM_000132.3

uniprot acc num :

P00451

ncbi mol weight :

24,641 Da

ncbi pathways :

Blood Clotting Cascade Pathway 198840!!Common Pathway 106060!!Complement And Coagulation Cascades Pathway 198880!!Complement And Coagulation Cascades Pathway 83073!!Complement And Coagulation Cascades Pathway 484!!Formation Of Fibrin Clot (Clotting Cascade) Pathway 106057!!Hemostasis Pathway 106028!!Intrinsic Pathway 106059!!Platelet Activation, Signaling And Aggregation Pathway 106034!!Platelet Degranulation Pathway 106050

ncbi summary :

This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia A, a common recessive X-linked coagulation disorder. [provided by RefSeq, Jul 2008]

size :

200 IU

price :

545 USD

more info or order :

MyBioSource product webpage