protein

Human Holo Transferrin

MBS142871

500 mg

305 USD

Native Protein

Human Holo Transferrin

Holo Transferrin

HTF Human; Holo Transferrin Human; Serotransferrin; Transferrin; Siderophilin; Beta-1-metal-binding globulin; TF; PRO1557; PRO2086; DKFZp781D0156; Holo Transferrin; HTF; Holo Transferrin

serotransferrin; Serotransferrin; serotransferrin; beta-1 metal-binding globulin; siderophilin; transferrin; Beta-1 metal-binding globulin; Siderophilin

TF; TF; TFQTL1; PRO1557; PRO2086; Transferrin

TRFE_HUMAN

698

Purity as determined by HPLC is 100%.

The protein (1mg/ml) was lyophilized with no additives. Sterile Filtered Pink lyophilized (freeze-dried) powder.

Holo Transferrin although stable at room temperature for 3 weeks, should be stored at 4 degree C.

Solubility: It is recommended to reconstitute the lyophilized Holo Transferrin in sterile 18M Omega -cm H2O not less than 100 ug/ml, which can then be further diluted to other aqueous solutions. Human Virus Test: FDA approved Plasma from each donor has been tested and found negative for antibody to HIV-1, HIV-2, HCV, HBSAG, HBc, ALT and Syphilis.Viral inactivation by pasteurization (60 degree C for 10 hours) has been validated using three different test viruses, with removal of 8-14.5 logs of virus documented. The purification process has also been found to remove significant additional quantities of virus.

RECOMBINANT & NATURAL PROTEINS; Natural Proteins; Transferrin

Description: Human Holo Transferrin is a glycoprotein of approximately 77 kDa containing 679 amino acids. Introduction: Transferrin is the iron-transport protein of vertebrate serum and donates iron to cells through interaction with a specific membrane receptor, CD71. Transferrin appears to be indispensable for most cells growing in tissue culture. It is referred to frequently as a growth factor because, in analogy to other growth factor-receptor interactions, proliferating cells express high numbers of transferrin receptors, and the binding of transferrin to their receptors is needed for cells to initiate and maintain their DNA synthesis. Apart from its role as an iron transport protein transferrin acts as a cytokine and has functions that may not be related to its iron-carrying capacity.Human Transferrin is a crucial component for the cultivation of mammalian cells in-vitro. Human Transferrin is Critical for long-term cells growth in-vitro. Human Transferrin is used as detoxificant in media by binding contaminating metal ions. Human Transferrin is often used as a nutrient in fermentation media for recombinant protein and biopharmaceutical production. Additional common uses of Human Transferrin areMolecular weight, Affinity purification of anti-human transferrin antibodies and also as receptor mediated transfection of molecules such as DNA, into cells.

4557871

NP_001054.1

NM_001063.3

P02787

77,064 Da

EPHB Forward Signaling Pathway 138047!!HIF-1 Signaling Pathway 695200!!HIF-1-alpha Transcription Factor Network Pathway 138045!!Hemostasis Pathway 106028!!Iron Metabolism In Placenta Pathway 672461!!Iron Uptake And Transport Pathway 187191!!Mineral Absorption Pathway 212237!!Mineral Absorption Pathway 212220!!Platelet Activation, Signaling And Aggregation Pathway 106034!!Platelet Degranulation Pathway 106050

This gene encodes a glycoprotein with an approximate molecular weight of 76.5 kDa. It is thought to have been created as a result of an ancient gene duplication event that led to generation of homologous C and N-terminal domains each of which binds one ion of ferric iron. The function of this protein is to transport iron from the intestine, reticuloendothelial system, and liver parenchymal cells to all proliferating cells in the body. This protein may also have a physiologic role as granulocyte/pollen-binding protein (GPBP) involved in the removal of certain organic matter and allergens from serum. [provided by RefSeq, Sep 2009]

500 mg

305 USD