protein

Recombinant Human Melanoma Antigen Family A, 1

MBS142867

0.002 mg

265 USD

Recombinant Protein

Recombinant Human Melanoma Antigen Family A, 1

Melanoma Antigen Family A

MAGEA1 Human; Melanoma Antigen Family A, 1 Human Recombinant; Melanoma-associated antigen 1; MAGE-1 antigen; Antigen MZ2-E; Cancer/testis antigen 1.1; CT1.1; MAGEA1; MAGE1; MAGE1A; MGC9326

melanoma-associated antigen 1; Melanoma-associated antigen 1; melanoma-associated antigen 1; MAGE-1 antigen; antigen MZ2-E; cancer/testis antigen 1.1; cancer/testis antigen family 1, member 1; melanoma antigen MAGE-1; melanoma antigen family A 1; melanoma antigen family A, 1 (directs expression of antigen MZ2-E); melanoma-associated antigen MZ2-E; melanoma antigen family A1; Antigen MZ2-E; Cancer/testis antigen 1.1; CT1.1; MAGE-1 antigen

MAGEA1

MAGEA1; MAGEA1; CT1.1; MAGE1; MAGE1; MAGE1A; CT1.1

MAGA1_HUMAN

E Coli

309

MAGEA1 in 50mM Tris-Acetate, pH7.5, 1mM EDTA and 20% Glycerol. Sterile Filtered clear solution.

Store vial at -20 degree C to -80 degree C. When stored at the recommended temperature, this protein is stable for 12 months.Please prevent freeze-thaw cycles.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Melanoma Antigen Family A

Description: MAGEA1 Human Recombinant full length protein expressed in E Coli, MAGEA1 is antibody reactive. The MAGEA1 is fused to a GST tag purified by proprietary chromatographic techniques. Introduction: Melanoma antigen family A 1 belongs to the MAGEA gene family, whose members encode proteins with 50 to 80% sequence identity to each other. The MAGEA genes which are clustered at chromosomal location Xq28, have been implicated in some hereditary disorders, such as dyskeratosis congenita.Human malignant neoplasms carry rejection antigens that are recognized by the patients autologous, tumor directed and specific, cytolytic, CD8+T lymphocyte clones (CTL). An important group of antigens is coded by the MAGE family of genes. It was identified that melanomas and primary glial brain tumors express common melanoma associated antigens (MAAs).Because MAGE-1 is expressed on a significant proportion of human neoplasms of various histological types (melanoma, brain tumors of glial origin, neuroblastoma, non-small cell lung cancer, breast, gastric, colorectal, ovarian, renal cell carcinomas) and not on normal tissues, the encoded antigen may serve as a marker of early detection and target for cancer immunotherapy.

148276977

NP_004979.3

NM_004988.4

P43355

34,342 Da

Delta-Notch Signaling Pathway (198879)

This gene is a member of the MAGEA gene family. The members of this family encode proteins with 50 to 80% sequence identity to each other. The promoters and first exons of the MAGEA genes show considerable variability, suggesting that the existence of this gene family enables the same function to be expressed under different transcriptional controls. The MAGEA genes are clustered at chromosomal location Xq28. They have been implicated in some hereditary disorders, such as dyskeratosis congenita. [provided by RefSeq, Jul 2008]

MAGE-A1: a tumor antigen expressed in a variety of tumor cells and in the testis. May play a role in embryonal development and tumor transformation or aspects of tumor progression. Antigen recognized on a melanoma by autologous cytolytic T-lymphocytes. Protein type: Cell surface. Chromosomal Location of Human Ortholog: Xq28. Cellular Component: cytoplasm; plasma membrane; nucleus. Molecular Function: protein binding; histone deacetylase binding. Biological Process: transcription, DNA-dependent; negative regulation of Notch signaling pathway; negative regulation of transcription from RNA polymerase II promoter

0.002 mg

265 USD

0.005 mg

365

0.01 mg

610