protein

Recombinant Human Cytokeratin 8 GST-Tag

MBS142854

0.002 mg

265 USD

Recombinant Protein

Recombinant Human Cytokeratin 8 GST-Tag

Cytokeratin 8

KRT8 Human, GST; Cytokeratin 8 Human Recombinant, GST Tag; Keratin type II cytoskeletal 8; Cytokeratin-8; CK-8; Keratin-8; K8; KRT8; CYK8; KO; CK8; K2C8; CARD2; KRT8 GST

keratin, type II cytoskeletal 8 isoform 2; Keratin, type II cytoskeletal 8; keratin, type II cytoskeletal 8; cytokeratin 8; cytokeratin-8; type-II keratin Kb8; keratin 8, type II; Cytokeratin-8; CK-8; Keratin-8; K8; Type-II keratin Kb8

KRT8

KRT8; KRT8; K8; KO; CK8; CK-8; CYK8; K2C8; CARD2; CYK8; CK-8; K8

K2C8_HUMAN

E Coli

483

Cytokeratin-8 in 50mM Tris-HCl pH-7.5, 10mM L-glutathione (reduced). Sterile Filtered clear solution.

Store vial at -20 degree C to -80 degree C. When stored at the recommended temperature, this protein is stable for 12 months.Please prevent freeze-thaw cycles.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Cytokeratin

Description: Cytokeratin 8 Human Recombinant full length protein expressed in E Coli, shows a 78 kDa SDS-PAGE.The Cytokeratin 8 is fused to GST-Tag and purified by proprietary chromatographic techniques. Introduction: Cytokeratin 8 belongs to the type B (basic) subfamily of high molecular weight keratins and exists in combination with keratin 18. Cytokeratin 8 is primarily found in the non-squamous epithelia and is present in majority of adenocarcinomas and ductal carcinomas. It is absent in squamous cell carcinomas. Hepatocellular carcinomas are defined by the use of antibodies that recognize only cytokeratin polypeptides 8 and 18.

372466577

NP_001243222.1

NM_001256293.1

P05787

56,608 Da

EGFR1 Signaling Pathway (198782); Signaling Mediated By P38-alpha And P38-beta Pathway (138012)

This gene is a member of the type II keratin family clustered on the long arm of chromosome 12. Type I and type II keratins heteropolymerize to form intermediate-sized filaments in the cytoplasm of epithelial cells. The product of this gene typically dimerizes with keratin 18 to form an intermediate filament in simple single-layered epithelial cells. This protein plays a role in maintaining cellular structural integrity and also functions in signal transduction and cellular differentiation. Mutations in this gene cause cryptogenic cirrhosis. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2012]

K8: a type II cytoskeletal keratin. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. Phosphorylation of keratins at specific sites affects their organization, assembly dynamics, and their interaction with signaling molecules. Phsophorylated by p38 kinase, regulating cellular keratin filament reorganization. Phosphorylation on serine residues is enhanced during EGF stimulation and mitosis. Mutation of this protein is a risk factor for cryptogenic liver failure. Protein type: Cytoskeletal. Chromosomal Location of Human Ortholog: 12q13. Cellular Component: dystrophin-associated glycoprotein complex; nucleoplasm; intermediate filament cytoskeleton; nuclear matrix; costamere; cytoplasm; keratin filament; intermediate filament; intercellular junction; Z disc; nucleus; sarcolemma. Molecular Function: protein binding; protein complex binding; structural molecule activity. Biological Process: viral reproduction; tumor necrosis factor-mediated signaling pathway; response to other organism; sarcomere organization; response to hydrostatic pressure. Disease: Cirrhosis, Familial

0.002 mg

265 USD

0.005 mg

365

0.01 mg

610