protein

Recombinant Human Microtubule-Associated Protein Tau

MBS142851

0.01 mg

205 USD

Recombinant Protein

Recombinant Human Microtubule-Associated Protein Tau

Microtubule-Associated Protein Tau

MAPT Human; Microtubule-Associated Protein Tau Human Recombinant; TAU; DDPAC; FTDP-17; MAPTL; MSTD; MTBT1; MTBT2; PPND

microtubule-associated protein tau isoform 6; Microtubule-associated protein tau; microtubule-associated protein tau; G protein beta1/gamma2 subunit-interacting factor 1; PHF-tau; microtubule-associated protein tau, isoform 4; neurofibrillary tangle protein; paired helical filament-tau; protein phosphatase 1, regulatory subunit 103; microtubule-associated protein tau; Neurofibrillary tangle protein; Paired helical filament-tau; PHF-tau

MAPT

MAPT; MAPT; TAU; MSTD; PPND; DDPAC; MAPTL; MTBT1; MTBT2; FTDP-17; PPP1R103; MAPTL; MTBT1; TAU; PHF-tau

TAU_HUMAN

E Coli

776

MGSSHHHHHH SSGLVPRGSH MAEPRQEFEV MEDHAGTYGL GDRKDQGGYT MHQDQEGDTD AGLKAEEAGI GDTPSLEDEA AGHVTQARMV SKSKDGTGSD DKKAKGADGK TKIATPRGAA PPGQKGQANA TRIPAKTPPA PKTPPSSGEP PKSGDRSGYS SPGSPGTPGS RSRTPSLPTP PTREPKKVAV VRTPPKSPSS AKSRLQTAPV PMPDLKNVKS KIGSTENLKH QPGGGKVQIV YKPVDLSKVT SKCGSLGNIH HKPGGGQVEV KSEKLDFKDR VQSKIGSLDN ITHVPGGGNK KIETHKLTFR ENAKAKTDHG AEIVYKSPVV SGDTSPRHLS NVSSTGSIDM VDSPQLATLA DEVSASLAKQ GL.

Greater than 85.0% as determined by SDS-PAGE.

The MAPT solution (0.5mg/ml) contains 20mM Tris-HCl pH-8, 1mM DTT, 0.2M NaCl & 10% glycerol. Sterile filtered colorless solution.

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Microtubule-Associated Protein

Description: MAPT Recombinant Human produced in E Coli is a single, non-glycosylated polypeptide chain containing 372 amino acids (1-352 a.a.) and having a molecular mass of 38.9 kDa (Real molecular weight on SDS-PAGE will be shift up). The MAPT is fused to a 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques. Introduction: MAPT is a neuronal microtubule associated protein localized mostly on axons. MAPT promotes tubulin polymerisation and stabilizes microtubules, however it also serves to connect certain signalling pathways to the cytoskeleton. MAPT, in its hyperphosphorylated form, is the main part of paired helical filaments (PHF) and neurofibrillary lesions in Alzheimer''s disease (AD) brain.

294862258

NP_001116538.2

NM_001123066.3

P10636

80,941 Da

Alzheimer's Disease Pathway 83097!!Alzheimer's Disease Pathway 509!!Alzheimers Disease Pathway 672448!!Apoptosis Pathway 105648!!Apoptotic Cleavage Of Cellular Proteins Pathway 105678!!Apoptotic Execution Phase Pathway 105677!!BDNF Signaling Pathway 712093!!Caspase-mediated Cleavage Of Cytoskeletal Proteins Pathway 105679!!IL-2 Signaling Pathway 198885!!IL-6 Signaling Pathway 198864

This gene encodes the microtubule-associated protein tau (MAPT) whose transcript undergoes complex, regulated alternative splicing, giving rise to several mRNA species. MAPT transcripts are differentially expressed in the nervous system, depending on stage of neuronal maturation and neuron type. MAPT gene mutations have been associated with several neurodegenerative disorders such as Alzheimer's disease, Pick's disease, frontotemporal dementia, cortico-basal degeneration and progressive supranuclear palsy. [provided by RefSeq, Jul 2008]

0.01 mg

205 USD