protein

Recombinant Human CD68, 38kda

MBS142849

0.002 mg

265 USD

Recombinant Protein

Recombinant Human CD68, 38kda

CD68

CD68 Human, 38kDa; CD68 Human Recombinant, 38kDa; Macrosialin; Gp110; CD68 antigen; CD68; SCARD1; DKFZp686M18236; CD68, 38 kda

macrosialin isoform B; Macrosialin; macrosialin; CD68 antigen; macrophage antigen CD68; scavenger receptor class D, member 1; CD68 molecule; Gp110; CD_antigen: CD68

CD68

CD68; CD68; GP110; LAMP4; SCARD1

CD68_HUMAN

E Coli

327

Greater than 90.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

CD68 at 100 ug/1ml in 50mM Tris-Acetate, pH7.5, 1mM EDTA, 20% Glycerol. Sterile Filtered clear solution.

Store vial at -20 degree C to -80 degree C. When stored at the recommended temperature, this protein is stable for 12 months.Please prevent freeze-thaw cycles.

RECOMBINANT & NATURAL PROTEINS; CD Antigens

Description: CD68 Human Recombinant full length expressed in E Coli, shows a 38 kDa band on SDS-PAGE.CD68 is purified by proprietary chromatographic techniques. Introduction: CD68 encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms.

91199550

NP_001035148.1

NM_001040059.1

P34810

34,654 Da

Lysosome Pathway (99052); Lysosome Pathway (96865)

This gene encodes a 110-kD transmembrane glycoprotein that is highly expressed by human monocytes and tissue macrophages. It is a member of the lysosomal/endosomal-associated membrane glycoprotein (LAMP) family. The protein primarily localizes to lysosomes and endosomes with a smaller fraction circulating to the cell surface. It is a type I integral membrane protein with a heavily glycosylated extracellular domain and binds to tissue- and organ-specific lectins or selectins. The protein is also a member of the scavenger receptor family. Scavenger receptors typically function to clear cellular debris, promote phagocytosis, and mediate the recruitment and activation of macrophages. Alternative splicing results in multiple transcripts encoding different isoforms. [provided by RefSeq, Jul 2008]

CD68: Could play a role in phagocytic activities of tissue macrophages, both in intracellular lysosomal metabolism and extracellular cell-cell and cell-pathogen interactions. Binds to tissue- and organ-specific lectins or selectins, allowing homing of macrophage subsets to particular sites. Rapid recirculation of CD68 from endosomes and lysosomes to the plasma membrane may allow macrophages to crawl over selectin-bearing substrates or other cells. Belongs to the LAMP family. 2 isoforms of the human protein are produced by alternative splicing. Protein type: Membrane protein, integral; Cell surface. Chromosomal Location of Human Ortholog: 17p13. Cellular Component: membrane; lysosomal membrane; plasma membrane; integral to membrane; endosome membrane

0.002 mg

265 USD

0.005 mg

365

0.01 mg

610