catalog number :
MBS142840
products type :
Recombinant Protein
products full name :
Recombinant Human Angiostatin Kringles 1-3
products short name :
Angiostatin Kringles 1-3
products name syn :
Ang K1-3 Human; Angiostatin Kringles 1-3 Human Recombinant; Angiostatin; Angiostatin Kringles 1-3; Ang K1-3; Angiostatin K1-3
sequence :
VYLSECKTGN GKNYRGTMSK TKNGITCQKW SSTSPHRPRF SPATHPSEGL EENYCRNPDN DPQGPWCYTT DPEKRYDYCD ILECEEECMH CSGENYDGKI SKTMSGLECQ AWDSQSPHAH GYIPSKFPNK NLKKNYCRNP DRELRPWCFT TDPNKRWELC DIPRCTTPPP SSGPTYQCLKGTGENYRGNV AVTVSGHTCQ HWSAQTPHTH NRTPENFPCK NLDENYCRNP DGKRAPWCHT TNSQVRWEYC KIPSCDSSP.
purity :
Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
form :
Lyophilized from a 0.2um filtered concentrated (1.0mg/ml) solution in 20mM NaAc, pH5.5, 4% mannitol. Sterile Filtered White lyophilized (freeze-dried) powder.
storage stability :
The lyophilized Angiostatin K1-3 is stable for several weeks at 2-8 degree C, but should be kept at -20 degree C for long term storage, preferably desiccated. Upon reconstitution, the preparation is stable for up to one week at 2-8 degree C. For maximal stability, apportion the reconstituted preparation into working aliquots and store at -20 degree C to -70 degree C. Avoid repeated freeze/thaw cycles.
other info2 :
Solubility: We recommend to briefly centrifuge the vial prior to opening to bring the contents to the bottom. Reconstitute in sterile distilled water or aqueous buffer containing 0.1% BSA to a concentration of 0.1-1.0 mg/ml. Stock solutions should be apportioned into working aliquots and stored at. Biological Activity: The activity is assayed on anti-proliferation and anti-migration of endothelial cells in vitro and anti-angiogenesis in vivo. The specific activity of anti-migration of endothelial cells in vitro is 55,000 Units/mg.
products categories :
RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins
products description :
Description: Angiostatin Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 259 amino acids and having a molecular mass of approximately 30.0 kDa. The Ang K1-3 is purified by proprietary chromatographic techniques. Introduction: Ang K1-3 is a proteolytic fragment of plasminogen containing the first three kringle structures. A specific inhibitor of endothelial cell growth and angiogenesis. More active relative to kringles 1-4. Ang K1-3 reduces endothelial cell proliferation and acts as a potent inhibitor of angiogenesis and tumor growth.