Recombinant Human Sirtuin-6 | MyBioSource MBS142838 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Sirtuin-6

catalog :

MBS142838

quantity :

0.002 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142838

products type :

Recombinant Protein

products full name :

Recombinant Human Sirtuin-6

products short name :

Sirtuin-6

products name syn :

SIRT6 Human; Sirtuin-6 Human Recombinant; Mono-ADP-ribosyltransferase sirtuin-6; SIR2-like protein 6; SIRT6; SIR2L6; Sirtuin-6

other names :

NAD-dependent protein deacetylase sirtuin-6 isoform 2; NAD-dependent protein deacetylase sirtuin-6; NAD-dependent protein deacetylase sirtuin-6; NAD-dependent deacetylase sirtuin-6; SIR2-like protein 6; regulatory protein SIR2 homolog 6; sir2-related protein type 6; sirtuin type 6; sirtuin 6; Regulatory protein SIR2 homolog 6; SIR2-like protein 6

products gene name :

SIRT6

other gene names :

SIRT6; SIRT6; SIR2L6; SIR2L6

uniprot entry name :

SIR6_HUMAN

host :

E Coli

sequence length :

328

sequence :

MGSSHHHHHH SSGLVPRGSH MSVNYAAGLS PYADKGKCGL PEIFDPPEEL ERKVWELARL VWQSSSVVFH TGAGISTASG IPDFRGPHGV WTMEERGLAP KFDTTFESAR PTQTHMALVQ LERVGLLRFL VSQNVDGLHV RSGFPRDKLA ELHGNMFVEE CAKCKTQYVR DTVVGTMGLK ATGRLCTVAK ARGLRACRGE LRDTILDWED SLPDRDLALA DEASRNADLS ITLGTSLQIR PSGNLPLATK RRGGRLVIVN LQPTKHDRHA DLRIHGYVDE VMTRLMEHLG LEIPAWDGPR VLERALPPLP RPPTPKLEPK EESPTRINGS IPAGPKQEPC AQHNGSEPAS PKRERPTSPA PHRPPKRVKA KAVPS.

purity :

Greater than 95.0% as determined by(a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

form :

The SIRT6 protein solution contains 20mM Tris-HCl pH-8 & 10% glycerol. Sterile Filtered colorless solution.

storage stability :

SIRT6 although stable 4 degree C for 4 weeks, should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

products categories :

RECOMBINANT & NATURAL PROTEINS; Recombinant Proteins; Sirtuin

products description :

Description: SIRT6 Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 375 amino acids (1-355 a.a.) and having a molecular mass of 41 kDa. Recombinant SIRT6 is fused to 20 amino acids His-tag at N-terminus and purified by conventional chromatography techniques. Introduction: SIRT6 is part of the sirtuin family of proteins (Class IV), homologs to the yeast Sir2 protein. SIRT6 is characterized by a sirtuin core domain. Yeast sirtuin proteins are recognized by their ability to regulate epigenetic gene silencing and suppress recombination of rDNA. SIRT6, a chromatin-associated protein is involved in DNA repair. Human Sirtuins function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity.

ncbi gi num :

300797597

ncbi acc num :

NP_001180214.1

ncbi gb acc num :

NM_001193285.1

uniprot acc num :

Q8N6T7

ncbi mol weight :

36,065 Da

ncbi pathways :

Central Carbon Metabolism In Cancer Pathway (1059538); Central Carbon Metabolism In Cancer Pathway (1084231); SREBF And MiR33 In Cholesterol And Lipid Homeostasis Pathway (755438); Signaling Events Mediated By HDAC Class I Pathway (137997)

ncbi summary :

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class IV of the sirtuin family. Alternative splicing results in multiple transcript variants.[provided by RefSeq, Jul 2010]

uniprot summary :

SIRT6: NAD-dependent protein deacetylase. Has deacetylase activity towards histone H3K9Ac and H3K56Ac. Modulates acetylation of histone H3 in telomeric chromatin during the S-phase of the cell cycle. Deacetylates histone H3K9Ac at NF-kappa-B target promoters and may down-regulate the expression of a subset of NF- kappa-B target genes. Acts as a corepressor of the transcription factor HIF1A to control the expression of multiple glycolytic genes to regulate glucose homeostasis. Required for genomic stability. Regulates the production of TNF protein. Has a role in the regulation of life span. Deacetylation of nucleosomes interferes with RELA binding to target DNA. May be required for the association of WRN with telomeres during S-phase and for normal telomere maintenance. Required for genomic stability. Required for normal IGF1 serum levels and normal glucose homeostasis. Modulates cellular senescence and apoptosis. On DNA damage, promotes DNA end resection via deacetylation of RBBP8. Has very weak deacetylase activity and can bind NAD(+) in the absence of acetylated substrate. Interacts with RELA. Interacts with RBBP8; the interaction deacetylates RBBP8. Belongs to the sirtuin family. Class IV subfamily. 3 isoforms of the human protein are produced by alternative splicing. Protein type: EC 2.4.2.31; Deacetylase; Transferase; EC 3.5.1.-. Chromosomal Location of Human Ortholog: 19p13.3. Cellular Component: nucleoplasm; intracellular membrane-bound organelle; nucleolus; nuclear telomeric heterochromatin; nucleus. Molecular Function: NAD(P)+-protein-arginine ADP-ribosyltransferase activity; protein binding; NAD-dependent histone deacetylase activity (H3-K9 specific); zinc ion binding; NAD-dependent histone deacetylase activity; chromatin binding; NAD+ ADP-ribosyltransferase activity. Biological Process: protein amino acid ADP-ribosylation; histone deacetylation

size1 :

0.002 mg

price1 :

140 USD

size2 :

0.01 mg

price2 :

205

size3 :

1 mg

price3 :

5015

more info or order :

MyBioSource product webpage