protein

Recombinant bovine Phosphoinositide 3-kinase a, regulatory subunit

MBS142822

0.002 mg

225 USD

Recombinant Protein

Recombinant bovine Phosphoinositide 3-kinase a, regulatory subunit

bPhosphoinositide 3-kinase a

p85a Bovine; Phosphoinositide 3-kinase a, regulatory subunit Bovine Recombinant; Phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase p85 subunit alpha; PtdIns-3-kinase p85-alpha; PI3K; P85a

phosphatidylinositol 3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase regulatory subunit alpha; phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase p85 subunit alpha; PI3-kinase regulatory subunit alpha; PI3-kinase subunit p85-alpha; PI3K regulatory subunit alpha; phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; phosphoinositide-3-kinase, regulatory subunit 1 (p85 alpha); phosphoinositide-3-kinase, regulatory subunit, polypeptide 1 (p85 alpha); ptdIns-3-kinase p85-alpha; ptdIns-3-kinase regulatory subunit alpha; ptdIns-3-kinase regulatory subunit p85-alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha

bP85a

PIK3R1; PIK3R1; PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha

P85A_BOVIN

Leishmania tarentolae

724

Greater than 90.0% as determined by SDS-PAGE.

Supplied as a 1 mg/ml solution in 25mM HEPES, pH 8.0, 25mM NaCl, 2.5mM MgCl2 and 50% glycerol. Sterile filtered liquid formualtion.

P85a although stable at 4 degree C for 1 week, should be stored desiccated below -18 degree C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

PROTEIN KINASES; Enzymes; Phosphoinositide 3-kinase

Description: Phosphoinositide 3-kinase subunit p85a Bovine Recombinant has a molecular weight of 83.5 kDa. Introduction: P85a functions as the regulatory subunit of the class IA PI3-kinase isoforms a, b, and d. It contains two SH2 domains that bind to tyrosine-phosphorylated growth factor receptors or substrate adaptor proteins.It also contains a BH (breakpoint cluster region homology) domain that shows GAP activity towards the small GTPases Rab4, Rab5, Cdc42, Rac1 and to a lesser extend towards Rab6 and Rab11.It was shown that PI3Ka catalytic subunit mediated phosphorylation of the p85a adapter reduces the lipid kinase activity of the heterodimer and this gives hints for PI3K-dependent signaling events not requiring production of 3'-phosphorylated phosphoinositides.PI3Ka protein kinase activity has been implicated in IRS-1 serine phosphorylation in insulin-treated adipocytes and in STAT3 and IRS-1 phosphorylation upon activation of the type 1 IFN receptor by IFN-a.

27807039

NP_777000.1

NM_174575.1

P23727

83,497 Da

AMPK Signaling Pathway (989258); AMPK Signaling Pathway (992181); Acute Myeloid Leukemia Pathway (84352); Acute Myeloid Leukemia Pathway (529); Adaptive Immune System Pathway (1119287); Adrenergic Signaling In Cardiomyocytes Pathway (908260); Adrenergic Signaling In Cardiomyocytes Pathway (909696); Aldosterone-regulated Sodium Reabsorption Pathway (130625); Aldosterone-regulated Sodium Reabsorption Pathway (130590); Alpha6-Beta4 Integrin Signaling Pathway (920929)

0.002 mg

225 USD

0.01 mg

360

0.02 mg

575