Recombinant Human Janus Kinase 2 | MyBioSource MBS142815 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Janus Kinase 2

catalog :

MBS142815

quantity :

0.005 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142815

products type :

Recombinant Protein

products full name :

Recombinant Human Janus Kinase 2

products short name :

Janus Kinase 2

other names :

protein kinase C delta type; Protein kinase C delta type; protein kinase C delta type; protein kinase C delta VIII; tyrosine-protein kinase PRKCD; protein kinase C, delta; Tyrosine-protein kinase PRKCD (EC:2.7.10.2); nPKC-deltaCleaved into the following 2 chains:Protein kinase C delta type regulatory subunit; Protein kinase C delta type catalytic subunitAlternative name(s):Sphingosine-dependent protein kinase-1; SDK1

products gene name :

JAK2

other gene names :

PRKCD; PRKCD; MAY1; PKCD; ALPS3; CVID9; nPKC-delta; SDK1

uniprot entry name :

KPCD_HUMAN

sequence length :

676

sequence :

MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMGE SPIFWYAPES LTESKFSVAS DVWSFGVVLY ELFTYIEKSK SPPAEFMRMI GNDKQGQMIV FHLIELLKNN GRLPRPDGCP DEIYMIMTEC WNNNVNQRPS FRDLALRVDQ IRDNMAG.

purity :

Greater than 95% as determined by SDS-PAGE.

form :

JAK2 protein solution (1mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M Urea.

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.

products categories :

PROTEIN KINASES

products description :

JAK2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing 157 amino acids (1014-1132 a.a) and having a molecular mass of 18.1kDa. JAK2 is fused to a 37 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques.

ncbi gi num :

31377782

ncbi acc num :

NP_006245.2

ncbi gb acc num :

NM_006254.3

ncbi mol weight :

80,953 Da

ncbi pathways :

AGE/RAGE Pathway (698754); Alpha-synuclein Signaling Pathway (137913); Alpha6-Beta4 Integrin Signaling Pathway (198807); Apoptosis Pathway (105648); Apoptotic Cleavage Of Cellular Proteins Pathway (105678); Apoptotic Execution Phase Pathway (105677); B Cell Receptor Signaling Pathway (198909); BDNF Signaling Pathway (712093); Ca-dependent Events Pathway (106497); CaM Pathway (106468)

ncbi summary :

Protein kinase C (PKC) is a family of serine- and threonine-specific protein kinases that can be activated by calcium and the second messenger diacylglycerol. PKC family members phosphorylate a wide variety of protein targets and are known to be involved in diverse cellular signaling pathways. PKC family members also serve as major receptors for phorbol esters, a class of tumor promoters. Each member of the PKC family has a specific expression profile and is believed to play distinct roles in cells. The protein encoded by this gene is one of the PKC family members. Studies both in human and mice demonstrate that this kinase is involved in B cell signaling and in the regulation of growth, apoptosis, and differentiation of a variety of cell types. Alternatively spliced transcript variants encoding the same protein have been observed. [provided by RefSeq, Jul 2008]

uniprot summary :

PKCD: an AGC kinase of the PKC family. A novel PKC: Ca2 independent but still regulated by PS, DAG and phorbol esters. Caspase-3 appears to liberate a sphingosine-activated catalytic fragment that has altered regulatory mechanisms and substrate specificities. Protein type: Tumor suppressor; Nuclear receptor co-regulator; EC 2.7.11.13; Kinase, protein; Protein kinase, AGC; Protein kinase, Ser/Thr (non-receptor); AGC group; PKC family; Delta subfamily. Chromosomal Location of Human Ortholog: 3p21.31. Cellular Component: nucleoplasm; nuclear matrix; mitochondrion; perinuclear region of cytoplasm; endoplasmic reticulum; cytoplasm; plasma membrane; intercellular junction; cytosol; nucleus. Molecular Function: calcium-independent protein kinase C activity; protein serine/threonine kinase activity; protein binding; protein kinase C activity; enzyme binding; metal ion binding; insulin receptor substrate binding; enzyme activator activity; non-membrane spanning protein tyrosine kinase activity; ATP binding. Biological Process: B cell proliferation; negative regulation of MAP kinase activity; interleukin-12 production; peptidyl-tyrosine phosphorylation; nerve growth factor receptor signaling pathway; apoptosis; negative regulation of insulin receptor signaling pathway; signal transduction; protein amino acid phosphorylation; positive regulation of protein amino acid dephosphorylation; negative regulation of filopodium formation; positive regulation of superoxide release; regulation of receptor activity; negative regulation of protein binding; cell structure disassembly during apoptosis; epidermal growth factor receptor signaling pathway; negative regulation of peptidyl-tyrosine phosphorylation; platelet activation; fibroblast growth factor receptor signaling pathway; protein stabilization; neutrophil activation; negative regulation of actin filament polymerization; cytokine and chemokine mediated signaling pathway; peptidyl-threonine phosphorylation; cell cycle; phospholipase C activation; negative regulation of inflammatory response; defense response to bacterium; interleukin-10 production; innate immune response; gene expression; immunoglobulin mediated immune response; vascular endothelial growth factor receptor signaling pathway; blood coagulation; induction of apoptosis by oxidative stress. Disease: Autoimmune Lymphoproliferative Syndrome, Type Iii

size1 :

0.005 mg

price1 :

140 USD

size2 :

0.02 mg

price2 :

205

size3 :

1 mg

price3 :

2665

more info or order :

MyBioSource product webpage