protein

Recombinant Human Uridine-Cytidine Kinase 1

MBS142811

0.005 mg

140 USD

Recombinant Protein

Recombinant Human Uridine-Cytidine Kinase 1

Uridine-Cytidine Kinase 1

tyrosine-protein kinase CSK; Tyrosine-protein kinase CSK; tyrosine-protein kinase CSK; C-Src kinase; protein-tyrosine kinase CYL; c-src tyrosine kinase; C-Src kinase; Protein-tyrosine kinase CYL

UCK1

CSK; CSK

CSK_HUMAN

450

C-SRC is supplied at a concentration of 0.29mg/ml in 50mM Tris, pH 7.6, 0.15 M NaCl, 0.27M sucrose, 1mM DTT, 0.1mM EGTA, 0.2mM PMSF, 1mM benzamidine, 5mM NaF, 10mM beta-glycerol phosphate, 0.1mM sodium vanadate and 0.03% Brij-35.

PROTEIN KINASES

187475373

NP_001120662.1

NM_001127190.1

50,704 Da

Adaptive Immune System Pathway (366160); B Cell Receptor Signaling Pathway (198909); BCR Signaling Pathway (138058); CXCR4-mediated Signaling Events Pathway (137910); Costimulation By The CD28 Family Pathway (119552); Disease Pathway (530764); EGFR1 Signaling Pathway (198782); Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway (83102); Epithelial Cell Signaling In Helicobacter Pylori Infection Pathway (515); GAB1 Signalosome Pathway (106341)

CSK: a tyrosine kinase of the Csk family that phosphorylates and inhibits Src family kinases. Specifically phosphorylates Y504 on LCK, which acts as a negative regulatory site. Csk and the phospho-tyrosine phosphatase CD45 reciprocally regulate phosphorylation of the inhibitory tyrosine of the Src family kinases Lck and Fyn during T-cell receptor mediated signaling during thymic development. Protein type: EC 2.7.10.2; Protein kinase, tyrosine (non-receptor); Protein kinase, TK; Kinase, protein; TK group; Csk family. Chromosomal Location of Human Ortholog: 15q24.1. Cellular Component: extrinsic to internal side of plasma membrane; cytoplasm; plasma membrane; intercellular junction; cytosol; lipid raft. Molecular Function: protein C-terminus binding; identical protein binding; protein binding; protein-tyrosine kinase activity; non-membrane spanning protein tyrosine kinase activity; protein phosphatase binding; ATP binding; receptor binding. Biological Process: epidermal growth factor receptor signaling pathway; negative regulation of kinase activity; negative regulation of phagocytosis; platelet activation; cell migration; central nervous system development; negative regulation of Golgi to plasma membrane protein transport; protein amino acid phosphorylation; T cell receptor signaling pathway; regulation of cytokine production; regulation of cell proliferation; positive regulation of MAP kinase activity; negative regulation of cell proliferation; T cell costimulation; negative regulation of interleukin-6 production; oligodendrocyte differentiation; morphogenesis of an epithelium; innate immune response; brain development; blood coagulation; cell differentiation; negative regulation of bone resorption; transmembrane receptor protein tyrosine kinase signaling pathway

0.005 mg

140 USD

0.025 mg

205

1 mg

2665