Recombinant Human Signal Transducer and Activator of Transcription 1 | MyBioSource MBS142809 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Signal Transducer and Activator of Transcription 1

catalog :

MBS142809

quantity :

0.002 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142809

products type :

Recombinant Protein

products full name :

Recombinant Human Signal Transducer and Activator of Transcription 1

products short name :

Signal Transducer and Activator of Transcription 1

products name syn :

STAT1 Human; Signal Transducer and Activator of Transcription 1 Human Recombinant; Signal transducer and activator of transcription 1-alpha/beta; Transcription factor ISGF-3 components p91/p84; STAT1; ISGF-3; STAT91; DKFZp686B04100

other names :

signal transducer and activator of transcription 1-alpha/beta isoform alpha; Signal transducer and activator of transcription 1-alpha/beta; signal transducer and activator of transcription 1-alpha/beta; signal transducer and activator of transcription 1, 91kD; signal transducer and activator of transcription-1; transcription factor ISGF-3 components p91/p84; signal transducer and activator of transcription 1, 91kDa; Transcription factor ISGF-3 components p91/p84

products gene name :

STAT1

other gene names :

STAT1; STAT1; CANDF7; IMD31A; IMD31B; IMD31C; ISGF-3; STAT91

uniprot entry name :

STAT1_HUMAN

host :

E Coli

sequence length :

750

sequence :

MGSSHHHHHH SSGLVPRGSH MSQWYELQQL DSKFLEQVHQ LYDDSFPMEI RQYLAQWLEK QDWEHAANDV SFATIRFHDL LSQLDDQYSR FSLENNFLLQ HNIRKSKRNL QDNFQEDPIQ MSMIIYSCLK EERKILENAQ RFNQAQSGNI QSTVMLDKQK ELDSKVRNVK DKVMCIEHEI KSLEDLQDEY DFKCKTLQNR EHETNGVAKS DQKQEQLLLK KMYLMLDNKR KEVVHKIIEL LNVTELTQNA LINDELVEWK RRQQSACIGG PPNACLDQLQ NWFTIVAESL QQVRQQLKKL EELEQKYTYE HDPITKNKQV LWDRTFSLFQ QLIQSSFVVE RQPCMPTHPQ RPLVLKTGVQ FTVKLRLLVK LQELNYNLKV KVLFDKDVNE RNTVKGFRKF NILGTHTKVM NMEESTNGSL AAEFRHLQLK EQKNAGTRTN EGPLIVTEEL HSLSFETQLC QPGLVIDLET TSLPVVVISN VSQLPSGWAS ILWYNMLVAE PRNLSFFLTP PCARWAQLSE VLSWQFSSVT KRGLNVDQLN MLGEKLLGPN ASPDGLIPWT RFCKENINDK NFPFWLWIES ILELIKKHLL PLWNDGCIMG FISKERERAL LKDQQPGTFL LRFSESSREG AITFTWVERS QNGGEPDFHA VEPYTKKELS AVTFPDIIRN YKVMAAENIP ENPLKYLYPN IDKDHAFGKY YSRPKEAPEP MELDGPKGTG YIKTELISVS EV.

purity :

Greater than 90% as determined by SDS-PAGE.

form :

STAT1 0.5mg/ml protein solution contains 20mM Tris-HCl buffer pH-8, 0.1M Nacl, 1mM DTT and 10% glycerol. Sterile Filtered clear solution.

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. Avoid multiple freeze-thaw cycles.

products categories :

PROTEIN KINASES; Enzymes; Protein Kinases

products description :

Description: STAT1 Recombinant Human produced in E Coli is a single, non-glycosylated polypeptide chain containing 732 amino acids (1-712 a.a.) and having a molecular mass of 85.2 kDa. The STAT1 is fused to 20 amino acid His-Tag at N-terminus and purified by proprietary chromatographic techniques. Introduction: STAT1 is a member of the Signal Transducers and Activators of Transcriptionfamily of transcription factors. STAT1 is involved in upregulating genes due to a signal by either type Ior type IIinterferons. In response to IFN-?stimulation, STAT1 forms homodimers or heterodimers with STAT3that bind to the GAS (Interferon-Gamma Activated Sequence) promoter element; in response to either IFN-? or IFN-?stimulation, STAT1 forms a heterodimer with STAT2that can bind the ISRE (Interferon Stimulated Response Element) promoter element. In either case, binding of the promoter element leads to an increased expression of ISG (Interferon Stimulated Genes).

ncbi gi num :

6274552

ncbi acc num :

NP_009330.1

ncbi gb acc num :

NM_007315.3

uniprot acc num :

P42224

ncbi mol weight :

83,043 Da

ncbi pathways :

AGE/RAGE Pathway (698754); Adipogenesis Pathway (198832); Antiviral Mechanism By IFN-stimulated Genes Pathway (530760); B Cell Receptor Signaling Pathway (198909); BDNF Signaling Pathway (712093); CXCR4-mediated Signaling Events Pathway (137910); Chemokine Signaling Pathway (99051); Chemokine Signaling Pathway (96864); Cytokine Signaling In Immune System Pathway (366171); Disease Pathway (530764)

ncbi summary :

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. This protein can be activated by various ligands including interferon-alpha, interferon-gamma, EGF, PDGF and IL6. This protein mediates the expression of a variety of genes, which is thought to be important for cell viability in response to different cell stimuli and pathogens. Two alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jul 2008]

uniprot summary :

STAT1: transcription factor of the STAT family. Phosphorylated and activated by receptor-associated kinases downstream of certain receptor tyrosine kinases, GPCRs, and receptors for various interleukins and interferons. Forms homo- or heterodimers that translocate into the nucleus where they regulate transcription. Two alternatively spliced isoforms have been described. Protein type: DNA-binding; Transcription factor. Chromosomal Location of Human Ortholog: 2q32.2. Cellular Component: nucleoplasm; axon; cytoplasm; dendrite; nuclear chromatin; nucleolus; cytosol; nucleus. Molecular Function: identical protein binding; signal transducer activity; protein binding; protein homodimerization activity; enzyme binding; double-stranded DNA binding; transcription factor activity; tumor necrosis factor receptor binding; CCR5 chemokine receptor binding. Biological Process: transcription from RNA polymerase II promoter; response to peptide hormone stimulus; response to cAMP; viral reproduction; apoptosis; blood circulation; positive regulation of transcription, DNA-dependent; positive regulation of smooth muscle cell proliferation; negative regulation of transcription from RNA polymerase II promoter; regulation of apoptosis; response to exogenous dsRNA; tumor necrosis factor-mediated signaling pathway; negative regulation of viral protein levels in host cell; positive regulation of mesenchymal cell proliferation; lipopolysaccharide-mediated signaling pathway; defense response to virus; response to nutrient; response to drug; cytokine and chemokine mediated signaling pathway; negative regulation of I-kappaB kinase/NF-kappaB cascade; JAK-STAT cascade; regulation of transcription from RNA polymerase II promoter; negative regulation of angiogenesis; cellular response to insulin stimulus; response to hydrogen peroxide; response to mechanical stimulus; response to cytokine stimulus; negative regulation of endothelial cell proliferation; endothelial cell migration; positive regulation of transcription from RNA polymerase II promoter. Disease: Immunodeficiency 31a; Immunodeficiency 31b; Immunodeficiency 31c

size1 :

0.002 mg

price1 :

140 USD

size2 :

0.01 mg

price2 :

205

size3 :

1 mg

price3 :

5015

more info or order :

MyBioSource product webpage