catalog number :
MBS142808
products type :
Recombinant Protein
products full name :
Recombinant Human Serine/Threonine Kinase 17A
products short name :
Serine/Threonine Kinase 17A
products name syn :
STK17A Human; Serine/Threonine Kinase 17A Human Recombinant; DRAK1; Serine/threonine-protein kinase 17A; DAP kinase-related apoptosis-inducing protein kinase 1; STK17A
other names :
serine/threonine-protein kinase 17A; Serine/threonine-protein kinase 17A; serine/threonine-protein kinase 17A; DAP kinase-related apoptosis-inducing protein kinase 1; death-associated protein kinase-related 1; serine/threonine kinase 17a (apoptosis-inducing); serine/threonine kinase 17a; DAP kinase-related apoptosis-inducing protein kinase 1
products gene name :
STK17A
other gene names :
STK17A; STK17A; DRAK1; DRAK1
uniprot entry name :
ST17A_HUMAN
purity :
Greater than 80.0% as determined by SDS-PAGE.
form :
STK17A protein solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol and 0.4M Urea. Sterile Filtered clear solution.
products categories :
PROTEIN KINASES; Enzymes; Protein Kinase-A
products description :
Description: STK17A Human Recombinant produced in E Coli is a single, non-glycosylated polypeptide chain containing 281 amino acids (64-321 a.a) and having a molecular mass of 31.9kDa.STK17A is fused to a 23 amino acid His-tag at N-terminus & purified by proprietary chromatographic techniques. Introduction: STK17A belongs to the DAP kinase-associated apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. STK17A acts as a positive regulator of apoptosis. STK17A is greatly expressed in the placenta with lower levels in the heart, lung, skeletal muscle, kidney and pancreas.
ncbi acc num :
NP_004751.2
ncbi gb acc num :
NM_004760.2
ncbi mol weight :
46,558 Da
ncbi summary :
This gene is a member of the DAP kinase-related apoptosis-inducing protein kinase family and encodes an autophosphorylated nuclear protein with a protein kinase domain. The protein has apoptosis-inducing activity. [provided by RefSeq, Jul 2008]
uniprot summary :
DRAK1: a calmodulin-dependent kinase of the DAPK family. Interacts with and is regulated by calcineurin homologous protein (CHP), an EF-hand Ca(2+)-binding protein. In vitro, CHP inhibits the apoptosis-inducing protein kinase DRAK2 in the presence of elevated Ca(2+) levels. Highly expressed in placenta, lung, pancreas. Lower levels in heart, brain, liver, skeletal muscle and kidney. Protein type: Kinase, protein; Protein kinase, CAMK; EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); CAMK group; DAPK family. Chromosomal Location of Human Ortholog: 7p13. Cellular Component: nucleus. Molecular Function: protein serine/threonine kinase activity; ATP binding. Biological Process: apoptosis; positive regulation of apoptosis; protein amino acid phosphorylation