protein

Recombinant Human Insulin Like Growth Factor-I Receptor

MBS142783

0.002 mg

265 USD

Recombinant Protein

Recombinant Human Insulin Like Growth Factor-I Receptor

Insulin Like Growth Factor-I

IGF-IR Human; Insulin-like Growth Factor-1 Receptor Human Recombinant; Insulin-like growth factor 1 receptor; EC 2.7.10.1; Insulin-like growth factor I receptor; IGF-I receptor; CD221 antigen; CD221; IGFIR; JTK13; MGC18216; MGC142170; MGC142172

insulin-like growth factor 1 receptor isoform 1; Insulin-like growth factor 1 receptor; insulin-like growth factor 1 receptor; IGF-I receptor; insulin-like growth factor I receptor; soluble IGF1R variant 1; soluble IGF1R variant 2; insulin-like growth factor 1 receptor; Insulin-like growth factor I receptor; IGF-I receptor; CD_antigen: CD221Cleaved into the following 2 chains:Insulin-like growth factor 1 receptor alpha chain; Insulin-like growth factor 1 receptor beta chain

IGF-IR

IGF1R; IGF1R; IGFR; CD221; IGFIR; JTK13; IGF-I receptor

IGF1R_HUMAN

E Coli

1367

IGF-IR protein in 50mM Tris-Acetate, pH-7.5, 1mM EDTA and 20% Glycerol. Sterile filtered liquid.

Store vial at -20 degree C to -80 degree C. When stored at the recommended temperature, this protein is stable for 12 months. Please avoid freeze-thaw cycles.

ELISA (EIA), Inhibition Assays, Western Blot (WB)

PROTEIN KINASES; Enzymes; Protein Kinases

Description: Insulin-like growth factor 1 receptor Human Recombinant encoding 1213-1367 amino acids expressed in E Coli, shows a 43kDa band on SDS-PAGE (Including GST tag).IGF-IR is purified by proprietary chromatographic techniques. Introduction: The Insulin-like Growth Factor 1 (IGF-1) Receptor is a transmembranereceptorthat is activated by IGF-1and by the related growth factor IGF-II. It belongs to the large class of tyrosine kinasereceptors. This receptor mediates the effects of IGF-1, which is a polypeptide protein hormone similar in molecular structure to insulin. IGF-1 plays an important role in growth and continues to have anabolic effects in adults - meaning that it can induce hypertrophy of skeletal muscleand other target tissues.IGF-1R (Insulin-like Growth Factor-1 Receptor) consists of alpha- and Beta-subunits, which are disulfide-linked in a Beta-alpha-alpha-Beta configuration in the mature receptor. The alpha-subunit is completely extracellular, while the Beta-subunit spans the membrane and the intracellular portion has intrinsic tyrosine kinase activity.

4557665

NP_000866.1

NM_000875.4

P08069

154,793 Da

AMPK Signaling Pathway (989139); AMPK Signaling Pathway (992181); Adherens Junction Pathway (83070); Adherens Junction Pathway (481); Apoptosis Pathway (198797); Endochondral Ossification Pathway (198812); Endocytosis Pathway (102279); Endocytosis Pathway (102181); Focal Adhesion Pathway (198795); Focal Adhesion Pathway (83067)

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, May 2014]

IGF1R: a receptor tyrosine kinase that binds insulin-like growth factor 1 (IGF1) with a high affinity and IGF2 with a lower affinity. Functions as an anti-apoptotic agent by enhancing cell survival. Can play a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. Tetramer of 2 alpha and 2 beta chains linked by disulfide bonds. The alpha chains contribute to the formation of the ligand- binding domain, while the beta chain carries the kinase domain. Interacts with PIK3R1 and with the PTB/PID domains of IRS1 and SHC1 in vitro when autophosphorylated on tyrosine residues. Mutated in rare cases of pre- and post-natal growth retardation. One SNP associated with increased human longevity. Increased expression of IGF1R and other pathway members associated with progression and malignancy in a range of cancers. Inhibitors: AG1024, AEW541. Protein type: Membrane protein, integral; EC 2.7.10.1; Protein kinase, TK; Protein kinase, tyrosine (receptor); Kinase, protein; TK group; InsR family. Chromosomal Location of Human Ortholog: 15q26.3. Cellular Component: neuron projection; membrane; intracellular membrane-bound organelle; integral to plasma membrane; plasma membrane; caveola; receptor complex. Molecular Function: insulin binding; identical protein binding; insulin-like growth factor binding; protein binding; insulin-like growth factor I binding; insulin receptor substrate binding; protein-tyrosine kinase activity; phosphoinositide 3-kinase binding; G-protein alpha-subunit binding; insulin receptor binding; insulin-like growth factor receptor activity; ATP binding. Biological Process: phosphoinositide 3-kinase cascade; epidermis development; inactivation of MAPKK activity; protein heterooligomerization; protein amino acid autophosphorylation; exocrine pancreas development; signal transduction; regulation of JNK cascade; response to vitamin E; positive regulation of MAPKKK cascade; mammary gland development; male sex determination; positive regulation of cell proliferation; protein tetramerization; positive regulation of cytokinesis; negative regulation of protein kinase B signaling cascade; phosphoinositide-mediated signaling; positive regulation of mitosis; negative regulation of transcription factor activity; positive regulation of protein kinase B signaling cascade; insulin-like growth factor receptor signaling pathway; axonogenesis; establishment of cell polarity; insulin receptor signaling pathway; immune response; brain development; positive regulation of DNA replication; negative regulation of apoptosis; positive regulation of cell migration. Disease: Insulin-like Growth Factor I, Resistance To

0.002 mg

265 USD

0.005 mg

365

0.01 mg

620