protein

Recombinant Human Hexokinase-4

MBS142782

0.01 mg

205 USD

Recombinant Protein

Recombinant Human Hexokinase-4

Hexokinase-4

GCK Human; Glucokinase/Hexokinase-4 Human Recombinant; Glucokinase; EC 2.7.1.2; Hexokinase-4; Hexokinase type IV; HK IV; HK4; Hexokinase-D; GCK; GK; GLK; HHF3; HKIV; HXKP; MODY2

glucokinase isoform 1; Glucokinase; glucokinase; ATP:D-hexose 6-phosphotransferase; HK IV; hexokinase D, pancreatic isozyme; hexokinase type IV; hexokinase-4; hexokinase-D; glucokinase (hexokinase 4); Hexokinase type IV; HK IV; Hexokinase-4; HK4; Hexokinase-D

GCK

GCK; GCK; GK; GLK; HK4; HHF3; HKIV; HXKP; LGLK; MODY2; FGQTL3; HK IV; HK4

HXK4_HUMAN

E Coli

465

Greater than 95.0% as determined by SDS-PAGE.

The protein (1mg/ml) contains 20mM Tris-HCl pH-8.0 and 10% glycerol. Sterile filtered colorless solution.

Store at 4 degree C if entire vial will be used within 2-4 weeks.Store, frozen at -20 degree C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please avoid freeze-thaw cycles.

PROTEIN KINASES; Enzymes; Hexokinase

Description: Glucokinase Human Recombinant produced in E Coli is a single, non-glycosylated, polypeptide chain (aa 1-465) fused to a 20aa His tag at the N-terminal encoding the sequence of 485 amino acids and having a molecular mass of 54.3 kDa.HK4 is purified by proprietary chromatographic techniques. Introduction: Hexokinases phosphorylate glucose to produce glucose-6-phosphate, thus committing glucose to the glycolytic pathway. Alternative splicing of Glucokinase results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, HK4 is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI).

4503951

NP_000153.1

NM_000162.3

P35557

52,035 Da

Amino Sugar And Nucleotide Sugar Metabolism Pathway 82979!!Amino Sugar And Nucleotide Sugar Metabolism Pathway 350!!Butirosin And Neomycin Biosynthesis Pathway 145809!!Butirosin And Neomycin Biosynthesis Pathway 145786!!Carbon Metabolism Pathway 814926!!Carbon Metabolism Pathway 817567!!Central Carbon Metabolism In Cancer Pathway 1059538!!Central Carbon Metabolism In Cancer Pathway 1084231!!Developmental Biology Pathway 477129!!Disease Pathway 530764

Hexokinases phosphorylate glucose to produce glucose-6-phosphate, the first step in most glucose metabolism pathways. Alternative splicing of this gene results in three tissue-specific forms of glucokinase, one found in pancreatic islet beta cells and two found in liver. The protein localizes to the outer membrane of mitochondria. In contrast to other forms of hexokinase, this enzyme is not inhibited by its product glucose-6-phosphate but remains active while glucose is abundant. Mutations in this gene have been associated with non-insulin dependent diabetes mellitus (NIDDM), maturity onset diabetes of the young, type 2 (MODY2) and persistent hyperinsulinemic hypoglycemia of infancy (PHHI). [provided by RefSeq, Apr 2009]

0.01 mg

205 USD