Recombinant Human Peroxisome Proliferator Activated Receptor Gamma | MyBioSource MBS142774 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Peroxisome Proliferator Activated Receptor Gamma

catalog :

MBS142774

quantity :

0.002 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142774

products type :

Recombinant Protein

products full name :

Recombinant Human Peroxisome Proliferator Activated Receptor Gamma

products short name :

Peroxisome Proliferator Activated Receptor Gamma

products name syn :

PPARG Human; Peroxisome Proliferator Activated Receptor Gamma Human Recombinant; Peroxisome proliferator-activated receptor gamma; PPAR-gamma; PPARG; NR1C3; PPARG1; PPARG2

other names :

peroxisome proliferator-activated receptor gamma isoform 1; Peroxisome proliferator-activated receptor gamma; peroxisome proliferator-activated receptor gamma; PPAR-gamma; nuclear receptor subfamily 1 group C member 3; peroxisome proliferator-activated nuclear receptor gamma variant 1; peroxisome proliferator-activated receptor gamma; Nuclear receptor subfamily 1 group C member 3

products gene name :

PPARG

other gene names :

PPARG; PPARG; GLM1; CIMT1; NR1C3; PPARG1; PPARG2; PPARgamma; NR1C3; PPAR-gamma

uniprot entry name :

PPARG_HUMAN

host :

E Coli

sequence length :

477

purity :

Greater than 90.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.

form :

The protein solution contains PBS, 50% glycerol and 0.01% azide. Sterile Filtered clear solution.

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks.Store, frozen at -20 degree C for longer periods of time.Avoid multiple freeze-thaw cycles.

other info2 :

Biological Activity: Specific activity is 3-4 units/ml obtained by measuring the increase of NADPH in absorbance at 340 nm resulting from the reduction of NADP. In the coupled mode, one unit will produce 1.0 umole of NADPH per minute as glucose is phosphorylated by ATP at pH 7.4 at 300C.

products categories :

PROTEIN KINASES; Enzymes; Peroxisome Proliferator Activated Receptor

products description :

Description: Peroxisome Proliferator Activated Receptor Gamma Human Recombinant is expressed in E Coli having a molecular weight of 59.2 kDa and fused to an amino terminal hexahistidine tag. Introduction: The peroxisome proliferator activated receptors (PPARs) are ligandactivated transcription factors within the nuclear receptor superfamily, which play important roles in adipogenesis, glucose homeostasis andinflammation. Three different isotypes can be distinguished; alpha, beta and gamma. PPARg, is mainly expressed in adipose tissue and to lesser extent in colon, the immune system and the retina. Whereas PPARg operates in the catabolism of fatty acids in the liver, PPARg influences the storage of fatty acids in the adipose tissue and plays a role in adipocyte differentiation. PPARg binds to DNA as a heterodimer with retinoid X receptor (RXR), activating expression of target genes after binding ligand.

ncbi gi num :

116284368

ncbi acc num :

NP_005028.4

ncbi gb acc num :

NM_005037.5

uniprot acc num :

P37231

ncbi mol weight :

21,580 Da

ncbi pathways :

AMPK Signaling Pathway (989139); AMPK Signaling Pathway (992181); Adipogenesis Pathway (198832); Calcineurin-regulated NFAT-dependent Transcription In Lymphocytes Pathway (137993); Developmental Biology Pathway (477129); Energy Metabolism Pathway (198907); Fatty Acid, Triacylglycerol, And Ketone Body Metabolism Pathway (160977); Gene Expression Pathway (105937); Generic Transcription Pathway (105938); Huntington's Disease Pathway (83100)

ncbi summary :

This gene encodes a member of the peroxisome proliferator-activated receptor (PPAR) subfamily of nuclear receptors. PPARs form heterodimers with retinoid X receptors (RXRs) and these heterodimers regulate transcription of various genes. Three subtypes of PPARs are known: PPAR-alpha, PPAR-delta, and PPAR-gamma. The protein encoded by this gene is PPAR-gamma and is a regulator of adipocyte differentiation. Additionally, PPAR-gamma has been implicated in the pathology of numerous diseases including obesity, diabetes, atherosclerosis and cancer. Alternatively spliced transcript variants that encode different isoforms have been described. [provided by RefSeq, Jul 2008]

uniprot summary :

PPAR-gamma: a transcription factor, member of the nuclear hormone receptor superfamily. Receptor for hypolipidemic drugs and fatty acids. Preferentially expressed in adipocytes as well as in vascular smooth muscle cells and macrophage. Regulator of adipogenesis and lipid metabolism, modulates insulin sensitivity, cell proliferation and inflammation. Phosphorylated and inhibited by MAP kinase. Heterodimerizes with the retinoid X receptor. Interacts with NCOA6 coactivator, leading to a strong increase in transcription of target genes. Two splice-variant isoforms have been described. Protein type: DNA-binding; Nuclear receptor. Chromosomal Location of Human Ortholog: 3p25. Cellular Component: nucleoplasm; perinuclear region of cytoplasm; cytosol; nucleus. Molecular Function: ligand-dependent nuclear receptor activity; transcription activator binding; zinc ion binding; drug binding; alpha-actinin binding; protein phosphatase binding; retinoid X receptor binding; arachidonic acid binding; protein binding; enzyme binding; DNA binding; ligand-dependent nuclear receptor transcription coactivator activity; prostaglandin receptor activity; sequence-specific DNA binding; steroid hormone receptor activity; estrogen receptor binding; chromatin binding; transcription factor activity. Biological Process: negative regulation of collagen biosynthetic process; heart development; positive regulation of transcription, DNA-dependent; cell maturation; rhythmic process; lipid homeostasis; response to lipid; glucose homeostasis; response to caffeine; response to vitamin A; positive regulation of oligodendrocyte differentiation; placenta development; long-chain fatty acid transport; organ regeneration; cell fate commitment; monocyte differentiation; negative regulation of acute inflammatory response; regulation of circadian rhythm; response to starvation; negative regulation of telomerase activity; cellular response to insulin stimulus; lipoprotein transport; response to estrogen stimulus; response to mechanical stimulus; brown fat cell differentiation; positive regulation of fat cell differentiation; positive regulation of transcription factor activity; positive regulation of transcription from RNA polymerase II promoter; steroid hormone mediated signaling; fatty acid oxidation; negative regulation of transcription, DNA-dependent; positive regulation of phagocytosis, engulfment; negative regulation of smooth muscle cell proliferation; low-density lipoprotein receptor biosynthetic process; negative regulation of transcription from RNA polymerase II promoter; signal transduction; epithelial cell differentiation; regulation of blood pressure; response to nutrient; caspase activation; transcription initiation from RNA polymerase II promoter; response to retinoic acid; G-protein coupled receptor protein signaling pathway; response to low density lipoprotein stimulus; white fat cell differentiation; positive regulation of fatty acid oxidation; innate immune response; gene expression; negative regulation of cell growth; lipid metabolic process; response to cold. Disease: Obesity; Carotid Intimal Medial Thickness 1; Lipodystrophy, Familial Partial, Type 3; Diabetes Mellitus, Noninsulin-dependent

size1 :

0.002 mg

price1 :

140 USD

size2 :

0.01 mg

price2 :

205

size3 :

1 mg

price3 :

4630

more info or order :

MyBioSource product webpage