Recombinant Human Mitogen-Activated Protein Kinase 1, Active | MyBioSource MBS142760 product information

product summary

company name :

MyBioSource

product type :

protein

product name :

Recombinant Human Mitogen-Activated Protein Kinase 1, Active

catalog :

MBS142760

quantity :

0.001 mg

price :

140 USD

more info or order :

MyBioSource product webpage

product information

catalog number :

MBS142760

products type :

Recombinant Protein

products full name :

Recombinant Human Mitogen-Activated Protein Kinase 1, Active

products short name :

[Mitogen-Activated Protein Kinase 1]

products name syn :

[MAPK1 Human, Active; Mitogen-Activated Protein Kinase 1 Human Recombinant, Active; Mitogen-activated protein kinase 1; EC 2.7.11.24; Extracellular signal-regulated kinase 2; ERK-2; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2; p42-MAPK; ERT1; ERK; p38; p40; p41; ERK2; MAPK2; PRKM1; PRKM2; P42MAPK; p41mapk; MAPK1 Active]

other names :

[mitogen-activated protein kinase 1; Mitogen-activated protein kinase 1; mitogen-activated protein kinase 1; MAP kinase 1; MAP kinase 2; MAP kinase isoform p42; MAPK 2; extracellular signal-regulated kinase 2; mitogen-activated protein kinase 2; protein tyrosine kinase ERK2; mitogen-activated protein kinase 1; ERT1; Extracellular signal-regulated kinase 2; ERK-2; MAP kinase isoform p42; p42-MAPK; Mitogen-activated protein kinase 2; MAP kinase 2; MAPK 2]

products gene name :

[MAPK1]

other gene names :

[MAPK1; MAPK1; ERK; p38; p40; p41; ERK2; ERT1; ERK-2; MAPK2; PRKM1; PRKM2; P42MAPK; p41mapk; p42-MAPK; ERK2; PRKM1; PRKM2; MAP kinase 1; MAPK 1; ERK-2; p42-MAPK; MAP kinase 2; MAPK 2]

uniprot entry name :

MK01_HUMAN

host :

E Coli

sequence length :

360

sequence :

maaaaaagag pemvrgqvfd vgprytnlsy igegaygmvc saydnvnkvr vaikkispfe hqtycqrtlr eikillrfrh eniigindii raptieqmkd vyivqdlmet dlykllktqh lsndhicyfl yqilrglkyi hsanvlhrdl kpsnlllntt cdlkicdfgl arvadpdhdh tgflteyvat rwyrapeiml nskgytksid iwsvgcilae mlsnrpifpg khyldqlnhi lgilgspsqe dlnciinlka rnyllslphk nkvpwnrlfp nadskaldll dkmltfnphk rieveqalah pyleqyydps depiaeapfk fdmelddlpk eklkelifee tarfqpgyrs

purity :

Greater than 95.0% as determined by SDS-PAGE.

form :

MAPK1 is supplied containing 50mM Tris-HCL, 150mM NaCl, 1mM DTT, 50% glycerol, pH 8.5. Sterile Filtered clear solution.

storage stability :

Store at 4 degree C if entire vial will be used within 2-4 weeks. Store, frozen at -20 degree C for longer periods of time. Avoid multiple freeze-thaw cycles.

other info1 :

Unit Defenition: 1 U = 1 pmol/min transferred to myelin basic protein at 30 degree C. Specific Activity: Specific Activity is 470.000 Units/mg.

products categories :

PROTEIN KINASES; Enzymes; Mitogen-Activated Protein Kinase

products description :

Description: MAPK1 Recombinant (extracellular signal-regulated kinase) a Mitogen-Activated Protein Kinase, is a highly active form produced by phosphorylation of the purified ERK2/MAPK1 in vitro with MEK1 is a non-glycosylated polypeptide chain containing amino acids 2-480 and having a molecular mass of 44.6 kDa. MAPK1 contains an amino terminal polyhistidine tag and is purified by proprietary chromatographic techniques. Introduction: Mitogen-activated protein kinase 1 (MAPK1) is also known as "extracellular signal-regulated kinase 2" (ERK2). Two similar (85% sequence identity) protein kinases were originally called ERK1 and ERK2. They were found during a search for protein kinases that are rapidly phosphorylated after activation of cell surface tyrosine kinasessuch as the epidermal growth factor receptor. Phosphorylation of ERKs leads to the activation of their kinase activity.The molecular events linking cell surface receptors to activation of ERKs are complex. It was found that RasGTP-binding proteins are involved in the activation of ERKs. Another protein kinase, Raf-1, was shown to phosphorylate a "MAPK kinase", thus qualifying as a "MAPK kinase kinase". The MAPK kinase was named "MAPK/ERK kinase" (MEK). Receptor-linked tyrosine kinases, Ras, Raf, MEK and MAPK could be fitted into a signaling cascade linking an extracellular signal to MAPK activation.Transgenic gene knockoutmice lacking MAPK1 have major defects in early development.

ncbi gi num :

66932916

ncbi acc num :

NP_002736.3

ncbi gb acc num :

NM_002745.4

uniprot acc num :

P28482

ncbi mol weight :

36,432 Da

ncbi pathways :

AGE/RAGE Pathway (698754); ALK1 Signaling Events Pathway (137968); ARMS-mediated Activation Pathway (106466); ATF-2 Transcription Factor Network Pathway (138006); Activated TLR4 Signalling Pathway (106400); Activation Of NMDA Receptor Upon Glutamate Binding And Postsynaptic Events Pathway (161033); Activation Of The AP-1 Family Of Transcription Factors Pathway (160139); Acute Myeloid Leukemia Pathway (83117); Acute Myeloid Leukemia Pathway (529); Adherens Junction Pathway (83070)

size1 :

0.001 mg

price1 :

140 USD

size2 :

0.005 mg

price2 :

205

size3 :

0.1 mg

price3 :

1995

more info or order :

MyBioSource product webpage